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a novel long non-coding RNA was found to silence its neighboring gene, Dppa2, in cis (show CISH Proteins) through recruiting Dnmt1 (show DNMT1 Proteins), Dnmt3a (show DNMT3A Proteins) and Dnmt3b (show DNMT3B Proteins)
Results identified a new family of pluripotency-related oncogenes consisting of DPPA2 and DPPA4 (show DPPA4 Proteins).
Results showed that the expression of Dppa2 decreased markedly in differentiated cells. Dppa2 might play a role in maintenance of the undifferentiated state and proliferation of ES cells
Study of expression and function of pluripotent markers such as Dppa2 and Dppa4 (show DPPA4 Proteins) is likely to unveil new aspects of the regulation of pluripotency and germ line development in mammals.
High DPPA2 Protein Expression is Associated with Gastric Cancer Metastasis
results showed that DPPA2 expression was significantly correlated to the depth of tumor invasion and progression of tumor cells through advanced stages in colorectal cancer.
A important role of HIWI (show PIWIL1 Proteins) and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells.
Differential expression of the embryo/cancer gene ECSA(DPPA2) in human preimplantation development (show MTA2 Proteins).
ECSA/DPPA2 is a promising target for antigen-specific immunotherapy in non-small cell lung cancers
In normal tissues, PLAC1 (show PLAC1 Proteins) expression was restricted to the placenta while DPPA2 expression was restricted to the placenta and testis.
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes (By similarity).
developmental pluripotency associated 2
, developmental pluripotency-associated protein 2
, protein DppA2
, developmental pluripotency-associated 2
, embryonic stem cell-associated transcript 15-2 protein
, pluripotent embryonic stem cell-related gene 1 protein
, cancer/testis antigen 100
, embryonic stem cell (ESC) associated transcript 15-2