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Smad2 (show SMAD2 Proteins) and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 (show SMAD2 Proteins) signalling complex in zebrafish.
Eomesa has a strictly maternal role in the initiation of epiboly, and is required for normal expression of the endoderm markers sox32, bon and og9x (show SEBOX Proteins); however it is not essential for endoderm formation.
Eomes is a Nodal-transducing factor that acts, directly and indirectly, in concert with FoxH1 (show FOXH1 Proteins) to carry out all Nodal-dependent processes during early mesendoderm specification.
Eomes plays a role in specifying the embryonic organizer.
regulates the expression of a zygotic homeobox (show PRRX1 Proteins) transcription factor mtx2 (show MTX2 Proteins)
Results suggest that eomesodermin promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the casanova promoter.
These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals.
the expression of T-bet, Eomes and GATA-3 (show GATA3 Proteins) in combination with additional differentiation molecules within CD4 (show CD4 Proteins)+ and CD8beta+ T cell subsets from different organs of healthy pigs.
EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56 (show NCAM1 Proteins)+ cell dysregulation.
we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib.
Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis.
the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects.
This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease.
This study supports the concept that poor human viral-specific CD8 (show CD8A Proteins)(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes
Report a global loss of 5hmC identified three new genes (ECM1 (show ECM1 Proteins), ATF5 (show ATF5 Proteins), and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression.
HHEX (show HHEX Proteins) promotes hepatic specification by repressing EOMES expression.
CD127 (show IL7R Proteins) is downregulated at a transcriptional level in memory CD8 (show CD8A Proteins) T cells in association with upregulation of Eomes expression in HIV infected patients.
The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.
as conceptuses attach to the uterine epithelium, IFNT gene transcription is down-regulated by an increase in EOMES expression and EOMES-CREBBP (show CREBBP Proteins) binding in the attached trophoblast cells.
Results indicated that Eomes bound to the Ifng (show IFNG Proteins) promoter and multiple conserved noncoding sequences in stimulation-dependent and stimulation-independent manners.
Demonstrate by using the T-box brain-2(Cre) mouse line that progenitor cells derived cells contribute 67.5% of glutamatergic but not GABAergic or astrocytic cells to all cortical layers including the earliest generated subplate zone.
a critical role for IRF4 (show IRF4 Proteins) in regulating protective anti-viral CD8 (show CD8A Proteins)+ T cell responses by ensuring a balanced ratio of T-bet to Eomes
Eomes expression is a key determinant of conventional NK versus Type 1 helper Innate Lymphoid Cell maturation following lineage specification.
T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset experimental autoimmune encephalomyelitis.
find that while stimulation of CD27 (show CD27 Proteins) in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8 (show CD8A Proteins)(+) T-cell responses to OVA immunization
The data identify a novel role for Eomes in CD4 (show CD4 Proteins)+ T cells and indicate that Eomes expression may act by limiting Foxp3 (show FOXP3 Proteins) induction, which may contribute to the association of EOMES to susceptibility to multiple sclerosis.
type I interferon (show IFNA Proteins) signalling in CD8 (show CD8A Proteins)(+) T cells drives Eomes expression.
TGF-beta (show TGFB1 Proteins)/tbr2 receptor signaling pathway may be required for prevention of beta cell death after initial cell proliferation following pancreatectomy.
Interleukin-4 (show IL4 Proteins) regulates eomesodermin in CD8 (show CD8A Proteins)+ T cell development and differentiation
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
eomesodermin homolog (Xenopus laevis)
, eomesodermin homolog
, T-box brain protein 2