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PRL-3 and Leo1 levels were positively associated in AML (show RUNX1 Proteins) patient samples.
The results show that the Paf1 (show PEX2 Proteins)/Leo1 heterodimer is necessary for its binding to histone H3 (show HIST3H3 Proteins), the histone octamer, and nucleosome in vitro.
Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 (show SLC12A1 Proteins) was identified.
results indicate that antagonistic regulation of gene expression by PAF1Cand p-TEFb (show CCNT1 Proteins) plays a crucial role in oligodendrocyte development in the CNS.
These results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations.
LEO1, parafibromin (CDC73\; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
, RNA polymerase-associated protein LEO1
, RNA polymerase-associated protein LEO1-like
, replicative senescence down-regulated leo1-like protein
, Paf1/RNA polymerase II complex component