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The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
Data show that mediator is recruited to the beta-globin (show HBB ELISA Kits) locus by the LDB1 complex.
Genome-wide analysis indicated that LMO2 (show LMO2 ELISA Kits) is required at the hemangioblast stage to position the TAL1 (show TAL1 ELISA Kits)/LMO2 (show LMO2 ELISA Kits)/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
LDB1 regulates energy homeostasis, in part through transcriptional modulation of critical regulators in brown adipose tissue function.
an essential cell-autonomous role for Ldb1 in the development of dopaminergic neurons, is reported.
An intricate regulatory network exists that is mediated by Ldb1 and Ldb2 (show LDB2 ELISA Kits), and promotes retinal progenitor cells proliferation and multipotency; it also controls specification of mammalian retina cells.
LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets.
CLIM interacts with estrogen receptor alpha (show ESR1 ELISA Kits) at the H19 (show NCKAP1 ELISA Kits) locus, potentially explaining the higher expression of H19 (show NCKAP1 ELISA Kits) in female than male corneas.
SSBP3 (show SSBP3 ELISA Kits) Interacts With Islet-1 (show ISL1 ELISA Kits) and Ldb1 to Impact Pancreatic beta-Cell Target Genes
the Isl1 (show ISL1 ELISA Kits)/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
results indicate that LDB1-dependent looping events can deliver repressive cargo to cognate promoters to mediate promoter pausing events in a pituitary cell type
Alanine scanning mutagenesis of the LIM (show PDLIM5 ELISA Kits) interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 (show LMO2 ELISA Kits) binding.
Clim2, in a complex with LMO4 (show LMO4 ELISA Kits), supports mammary stem cells by directly targeting the Fgfr2 (show FGFR2 ELISA Kits) promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1 (show RUNX1 ELISA Kits)-ETO (show RUNX1T1 ELISA Kits)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin (show HBB ELISA Kits) locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma (show TRIM33 ELISA Kits) acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4 (show LMO4 ELISA Kits):ldb1 complex
Ssdp (show SSBP3 ELISA Kits) proteins interact with the LIM (show PDLIM5 ELISA Kits)-domain-binding protein Ldb1 to regulate development
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2 (show CBFA2T3 ELISA Kits), the cyclin-dependent kinase (show CDK1 ELISA Kits) Cdk9 (show CDK9 ELISA Kits), Lmo4 (show LMO4 ELISA Kits); morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, neural Src-interacting protein
, neural src interacting protein
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, LIM-domain binding factor 1