Browse our Nanog Homeobox Proteins (NANOG)

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Nanog Homeobox Proteins (NANOG)
On are 18 Nanog Homeobox (NANOG) Proteins from 8 different suppliers available. Additionally we are shipping Nanog Homeobox Antibodies (406) and Nanog Homeobox Kits (9) and many more products for this protein. A total of 450 Nanog Homeobox products are currently listed.
2410002E02Rik, ecat4, ENK
list all proteins Gene Name GeneID UniProt
NANOG 71950 Q80Z64
NANOG 79923 Q9H9S0
Rat NANOG NANOG 414065  

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Nanog Homeobox Proteins (NANOG) by Origin

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Top referenced Nanog Homeobox Proteins

  1. Human NANOG Protein expressed in Escherichia coli (E. coli) - ABIN667930 : Pan, Pei: Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog. in Cell research 2004 (PubMed)
    Show all 2 references for 667930

More Proteins for Nanog Homeobox Interaction Partners

Mouse (Murine) Nanog Homeobox (NANOG) interaction partners

  1. Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (show SOX2 Proteins) heterodimerization and self-renewal activity.

  2. In mouse model of acute uterine injury, Nanog homebox (NANOG) express (show SRY Proteins)ion reached (show SOX2 Proteins) a peak at 6 h, while sex-determining (show POU5F1 Proteins) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment.

  3. NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.

  4. Data indicate that Nanog homeobox protein (show HOXA1 Proteins) is important for the effects of reprogramming media.

  5. Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (show CDKN1B Proteins) gene.

  6. The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins) and Klf4 (show KLF4 Proteins) expression, or cell cycle phase.

  7. 1After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages

  8. Nanog is able to transform normal somatic cells into tumor cells.

  9. NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.

  10. The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.

Human Nanog Homeobox (NANOG) interaction partners

  1. Nanog directly repressed transcription of the miR (show MLXIP Proteins)-200c and miR (show MLXIP Proteins)-200b genes in colon cancer cells, inducing epithelial-mesenchymal transformation.

  2. LGR5 (show LGR5 Proteins)-expressing fraction of CD54 (show ICAM1 Proteins)+ cells represents gastric cancer CSCs, in which LGR5 (show LGR5 Proteins) is closely associated with stemness and EMT (show ITK Proteins) core genes

  3. Data show that Nanog homebox (NANOG) but not sex-determining region Y (show SRY Proteins)-box2 (SOX2 (show SOX2 Proteins)) and octamer-binding protein 4 (OCT4 (show POU5F1 Proteins)) expression was overexpressed in the endometrium of women with intrauterine adhesion (IUA).

  4. The NANOG transcription was significantly upregulated by ETV4 (show ETV4 Proteins) overexpression.

  5. Collectively, these findings demonstrate a novel role of YBX1 (show YBX1 Proteins) in maintaining the stemness of CSCs and metastasis, unveiling YBX1 (show YBX1 Proteins) as promising therapeutic target for NSCLC treatments.

  6. the early response of pluripotency genes OCT4 (show POU5F1 Proteins) and NANOG to the differentiation-inducing stimuli is mediated by dynamic changes in chromatin marks, while DNA methylation (show HELLS Proteins) is acquired in the later stages of neurogenesis.

  7. USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG

  8. Nanog expression is a prognostic biomarkers for triple-negative breast cancer

  9. Stat3 (show STAT3 Proteins) was correlated with NANOG-mediated EMT (show ITK Proteins).

  10. miR-760 was proved to be functional associated with NANOG via regulating its expression.

Pig (Porcine) Nanog Homeobox (NANOG) interaction partners

  1. Activin A (show INHBA Proteins) and overexpression of SMAD2 (show SMAD2 Proteins)/3 significantly promoted expressions of porcine NANOG and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (show POU5F1 Proteins) expression.

  2. the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.

  3. Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.

  4. Localisation of NANOG, OCT4 (show POU5F1 Proteins), and E-CADHERIN (show CDH1 Proteins) in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.

Cow (Bovine) Nanog Homeobox (NANOG) interaction partners

  1. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  2. Nanog displayed relatively the same methylation levels between sperm and oocytes

  3. Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.

Nanog Homeobox (NANOG) Protein Profile

Protein Summary

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

Alternative names and synonyms associated with Nanog Homeobox (NANOG)

  • Nanog homeobox (Nanog)
  • Nanog homeobox (NANOG)
  • 2410002E02Rik protein
  • ecat4 protein
  • ENK protein

Protein level used designations for Nanog Homeobox Proteins (NANOG)

ES cell-associated protein 4 , early embryo specific expression NK family , early embryo specific expression NK-type homeobox protein , homeobox protein NANOG , homeobox transcription factor Nanog , hNanog , homeobox transcription factor Nanog-delta 48 , homeodomain transcription factor Nanog , homeobox transcription factor NANOG

71950 Mus musculus
79923 Homo sapiens
100170132 Sus scrofa
538951 Bos taurus
486701 Canis lupus familiaris
100860956 Capra hircus
414065 Rattus norvegicus
748301 Pan troglodytes
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