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Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (show OTX2 Proteins)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (show MTA2 Proteins).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), and Nanog; Trim24 (show TRIM24 Proteins) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L (show BNIP3L Proteins) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.
Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (show SOX2 Proteins) heterodimerization and self-renewal activity.
In mouse model of acute uterine injury, Nanog homebox (NANOG) express (show SRY Proteins)ion reached (show SOX2 Proteins) a peak at 6 h, while sex-determining (show POU5F1 Proteins) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment.
NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.
Data indicate that Nanog homeobox protein (show HOXA1 Proteins) is important for the effects of reprogramming media.
Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (show CDKN1B Proteins) gene.
High NANOG expression is associated with Multidrug Resistance in breast and cervical cancer.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
These data reveal an overexpression of NANOG and other markers of pluripotency and stemness in meningiomas.
The NANOG deficiency affected multiple genes, particularly, supressed drug-resistance via down-regulated ABCG2 in Eca109 cells, and caused G1 arrest by down-regulated cyclin D1 (CCND1 (show CCND1 Proteins)) expression.
Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2 (show SOX2 Proteins), OCT3/4 (show POU5F1 Proteins) and NANOG (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM (show EPCAM Proteins)(+) and CD90 (show THY1 Proteins)(-)).
Data suggest that C-terminal truncated hepatitis B virus X protein (HBx-DeltaC1) enhances liver cancer stem cell (CSC) properties through Stat3 (show STAT3 Proteins)/Nanog cascade, and insight for the therapeutic intervention for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC (show FAM126A Proteins)).
Nanog directly repressed transcription of the miR (show MLXIP Proteins)-200c and miR (show MLXIP Proteins)-200b genes in colon cancer cells, inducing epithelial-mesenchymal transformation.
LGR5 (show LGR5 Proteins)-expressing fraction of CD54 (show ICAM1 Proteins)+ cells represents gastric cancer CSCs, in which LGR5 (show LGR5 Proteins) is closely associated with stemness and EMT (show ITK Proteins) core genes
Data show that Nanog homebox (NANOG) but not sex-determining region Y (show SRY Proteins)-box2 (SOX2 (show SOX2 Proteins)) and octamer-binding protein 4 (OCT4 (show POU5F1 Proteins)) expression was overexpressed in the endometrium of women with intrauterine adhesion (IUA).
The NANOG transcription was significantly upregulated by ETV4 (show ETV4 Proteins) overexpression.
Activin A (show INHBA Proteins) and overexpression of SMAD2 (show SMAD2 Proteins)/3 significantly promoted expressions of porcine NANOG and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (show POU5F1 Proteins) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Proteins), and E-CADHERIN (show CDH1 Proteins) in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeodomain transcription factor Nanog
, homeobox transcription factor NANOG