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Human NANOG Protein expressed in Escherichia coli (E. coli) - ABIN667930
Pan, Pei: Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog. in Cell research 2004
Show all 2 references for ABIN667930
NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.
Data indicate that Nanog homeobox protein (show HOXA1 Proteins) is important for the effects of reprogramming media.
Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (show CDKN1B Proteins) gene.
The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins) and Klf4 (show KLF4 Proteins) expression, or cell cycle phase.
1After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages
Nanog is able to transform normal somatic cells into tumor cells.
NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.
The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.
the existence of three stable steady states for Nanog levels, which are the same in all the different conditions of the cell-culture medium.
NANOG binds to GLI1 (show GLI1 Proteins) and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.
Nanog expression is a prognostic biomarkers for triple-negative breast cancer
Stat3 (show STAT3 Proteins) was correlated with NANOG-mediated EMT (show ITK Proteins).
miR-760 was proved to be functional associated with NANOG via regulating its expression.
SIRT-1 and NANOG are high correlated biological markers for diagnosis and prognosis follow up in patients with adenocarcinoma.
renal cell carcinoma (show MOK Proteins) patients with low Nanog and Oct4 (show POU5F1 Proteins) expressions in tumor tissues had significantly higher survival rates (p < 0.05). High Nanog and Oct4 (show POU5F1 Proteins) expressions may be potential therapeutic targets.
ANOG was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 Proteins) phosphorylation in colorectal cancer (CRC (show CALR Proteins)). This coincides with that IGF receptor IGF-1R (show IGF1R Proteins) is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 Proteins)/NANOG/Slug (show SNAI2 Proteins) signaling axis in the progression of CRC (show CALR Proteins)
Nanog is a positive regulator of cervical cancer dedifferentiation.
Data show that long intergenic non-protein coding RNA ROR may act as a competitive endogenous RNAs (ceRNAs), effectively becoming a sink for microRBA miR-145, thereby activating the derepression of core transcription factors Nanog.
ALKBH5 overexpression decreased NANOG mRNA methylation, increased NANOG levels, and increased the percentage of BCSCs, phenocopying the effect of hypoxia
Expression levels of OCT4, SOX2, and NANOG were evaluated by immunohistochemistry with tissue microarray slides of 436 OSCC, 362 corresponding tumor-adjacent normal (CTAN) tissues, and 71 normal uvula epithelium tissues.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Proteins), and E-CADHERIN (show CDH1 Proteins) in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeodomain transcription factor Nanog
, homeobox transcription factor NANOG