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Browse our anti-OCT4 (POU5F1) Antibodies

Full name:
anti-POU Class 5 Homeobox 1 Antibodies (POU5F1)
On are 407 POU Class 5 Homeobox 1 (POU5F1) Antibodies from 35 different suppliers available. Additionally we are shipping OCT4 Kits (42) and OCT4 Proteins (19) and many more products for this protein. A total of 492 OCT4 products are currently listed.
cb197, chunp6868, gp-9, gp9, NF-A3, Oct-3, Oct-3/4, Oct-4, Oct3, Oct3/4, oct4, Otf-3, Otf-4, Otf3, Otf3-rs7, Otf3g, Otf4, POU-2, pou2, POU5F1, POU5F1L, spg/pou2, wu:fd18d06
list all antibodies Gene Name GeneID UniProt
POU5F1 5460 Q01860
POU5F1 294562  
POU5F1 18999 P20263

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All available anti-OCT4 Antibodies

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Top referenced anti-OCT4 Antibodies

  1. Human Polyclonal OCT4 Primary Antibody for EIA, IHC (p) - ABIN357429 : Looijenga, Stoop, de Leeuw, de Gouveia Brazao, Gillis, van Roozendaal, van Zoelen, Weber, Wolffenbuttel, van Dekken, Honecker, Bokemeyer, Perlman, Schneider, Kononen, Sauter, Oosterhuis: POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. in Cancer research 2003 (PubMed)
    Show all 5 references for ABIN357429

  2. Human Polyclonal OCT4 Primary Antibody for IHC (p), WB - ABIN655493 : Abu-Remaileh, Gerson, Farago, Nathan, Alkalay, Zins Rousso, Gur, Fainsod, Bergman: Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. in The EMBO journal 2010 (PubMed)
    Show all 5 references for ABIN655493

  3. Human Polyclonal OCT4 Primary Antibody for EIA, IF - ABIN357427 : Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003 (PubMed)
    Show all 5 references for ABIN357427

  4. Human Polyclonal OCT4 Primary Antibody for IF, WB - ABIN388788 : Crouau-Roy, Amadou, Bouissou, Clayton, Vernet, Ribouchon, Pontarotti: Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. in Genomics 1994 (PubMed)
    Show all 4 references for ABIN388788

  5. Human Polyclonal OCT4 Primary Antibody for IF, WB - ABIN388789 : Takeda, Seino, Bell: Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. in Nucleic acids research 1992 (PubMed)
    Show all 4 references for ABIN388789

  6. Human Monoclonal OCT4 Primary Antibody for IHC (p) - ABIN263985 : Jones, MacLennan, Bonnin, Varsegi, Blair, Cheng: Screening for intratubular germ cell neoplasia of the testis using OCT4 immunohistochemistry. in The American journal of surgical pathology 2006 (PubMed)
    Show all 3 references for ABIN263985

  7. Human Polyclonal OCT4 Primary Antibody for WB - ABIN783318 : Pan, Thomson: Nanog and transcriptional networks in embryonic stem cell pluripotency. in Cell research 2007 (PubMed)
    Show all 3 references for ABIN783318

  8. Dog (Canine) Polyclonal OCT4 Primary Antibody for WB - ABIN2792671 : Suo, Han, Wang, Zhang, Zhao, Zhao, Dai: Oct4 pseudogenes are transcribed in cancers. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 3 references for ABIN2792671

  9. Human Polyclonal OCT4 Primary Antibody for ELISA, WB - ABIN185438 : Jones, Ulbright, Eble, Baldridge, Cheng: OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. in The American journal of surgical pathology 2004 (PubMed)
    Show all 2 references for ABIN185438

  10. Cow (Bovine) Polyclonal OCT4 Primary Antibody for WB - ABIN2778604 : Palma, Peña, Contreras, Ceballos-Reyes, Coyote, Eraña, Kofman-Alfaro, Queipo: Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation. in Cancer letters 2008 (PubMed)

More Antibodies against OCT4 Interaction Partners

Human POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Data show that Nanog homebox (NANOG) but not (show NANOG Antibodies)sex-determining (show NANOG Antibodies) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) express (show SRY Antibodies)ion was ove (show SOX2 Antibodies)rexpressed in the endometrium of women with intrauterine adhesion (IUA).

  2. HPV16 E7 oncoprotein upregulates Oct3/4, Sox2 (show SOX2 Antibodies), Nanog (show NANOG Antibodies) and Fgf4 (show FGF4 Antibodies) expression to maintain the self-renewal capacity of cancer stem cells.

  3. the early response of pluripotency genes OCT4 and NANOG (show NANOG Antibodies) to the differentiation-inducing stimuli is mediated by dynamic changes in chromatin marks, while DNA methylation (show HELLS Antibodies) is acquired in the later stages of neurogenesis.

  4. The data indicate that both OCT4 and SOX2 (show SOX2 Antibodies) play important roles in the development of Barrett Esophagus triggered by bile acid reflux.

  5. Oct4/Lys (show LYZ Antibodies)-156-modulated Oct4/Sox2 (show SOX2 Antibodies) interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals.

  6. Oct-4 signaling is modulated by nodal via nuclear translocation of beta-catenin (show CTNNB1 Antibodies) in lung and prostate cancer cells

  7. High Oct4 expression is associated with glioma.

  8. Increased expression of epithelial OCT4, SOX15 (show SOX15 Antibodies) and TWIST1 (show TWIST1 Antibodies) was detected in endometriotic tissue compared to endometriosis patient endometrium. Epithelial expression of OCT4, SOX15 (show SOX15 Antibodies), and TWIST1 (show TWIST1 Antibodies) was increased in the endometrium of endometriosis patients compared to controls.

  9. All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.

  10. Oct4+Sox2 (show SOX2 Antibodies)+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.

Pig (Porcine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos.

  2. These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding.

  3. Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells.

  4. showed novel molecular regulation of CDX2 (show CDX2 Antibodies) on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 (show CDX2 Antibodies) and Oct4 in embryo of mammals other than mouse

  5. Overexpression of Sox2 (show SOX2 Antibodies) or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.

  6. Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication.

  7. study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass

  8. OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.

  9. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level.

  10. in the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively

Cow (Bovine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes

  4. In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.

  5. analysis of CpG islands of bovine Leptin (show LEP Antibodies) and POU5F1 genes in cloned bovine fetuses

  6. The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.

Rabbit POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. sequences of mRNA and translated protein of the newly identified genes and those of POU5F1 were aligned to their mammalian orthologs to determine the degree of evolutionary conservation

  2. Higher values of OCT-4 expression were observed in embryos and endometrial tissue in females reproduced under heat conditions.

  3. protein expression during rabbit embryonic development: investigation of temporal and spatial relationship of expression of Oct-4, Cdx-2 (caudal type homeobox transcription factor 2 (show CDX2 Antibodies)) and histone H4 (acetylated at lysine 5) in morula/blastocysts

  4. The signal may have reflected the regulation of Oct-4 through enhancer switching and therefore may be related to cell lineage formation in rabbit embryos.

  5. The POU5F1 gene is strictly regulated during early embryo development.

Rhesus Monkey POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Cytoplasmic CD44 (show CD44 Antibodies) and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.

  2. Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.

Mouse (Murine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. In mouse model of acute uterine injury, Nanog (show NANOG Antibodies) homebox (NANOG (show NANOG Antibodies)) expression reached a peak at 6 h, while sex-determining region Y (show SRY Antibodies)-box2 (SOX2 (show SOX2 Antibodies)) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS (show TLR4 Antibodies)) treatment.

  2. Here, the authors present the first structure of mouse GCNF (show NR6A1 Antibodies) DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter.

  3. Data show that expression of the Oct-4, Sox2 (show SOX2 Antibodies), Klf4 (show KLF4 Antibodies), and c-Myc (show MYC Antibodies) (OSKM) reprogramming factors induces Cyclin D1 (show CCND1 Antibodies) expression, and the increased Cyclin D1 (show CCND1 Antibodies) expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.

  4. In late preimplantation, Oct4 served as a chromatin opener to create transcriptional permissive states at Xm-Xist/Tsix genomic loci. In parthenogenetic embryos, Rnf12 (show RLIM Antibodies) overdose caused Xm-Xist derepression via Xm-Tsix repression; physiological Rnf12 (show RLIM Antibodies) levels were essential for Xm-Xist silencing maintenance in fertilized embryos.

  5. Data show that the reprogramming factors OCT4, SOX2 (show SOX2 Antibodies), KLF4 (show KLF4 Antibodies), and MYC (show MYC Antibodies) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  6. Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming.

  7. our study provides valuable information on the molecular interactions between OSKM(Oct4, Sox2 (show SOX2 Antibodies), Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a (show SETD1A Antibodies) in ESCs (show NR2E3 Antibodies) and early development

  8. Hierarchical Oct4 binding in concert with primed epigenetic rearrangements during somatic cell reprogramming has been described.

  9. One-week administration of valproic acid followed by one-week forced expression of Oct4 enhanced myelination by converting transduced cells to myelinating oligodendrocytes

  10. Aurkb (show AURKB Antibodies) phosphorylates Oct4(S229) during G2/M phase, leading to the dissociation of Oct4 from chromatin, whereas PP1 (show PPP1CC Antibodies) binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle.

Zebrafish POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Regulation of mych by Pou5f1 appears to be direct transcriptional activation.

  2. The posttranslational modification by phosphorylation opens the possibility that Pou5f1 may be subject to temporal or region specific modulation of its activity or stability by embryonic signaling mechanisms.

  3. discuss mechanistic implications of simultaneous activation of transcriptional targets by ubiquitous, like Pou5f1, and region-specific inducers, emerging as a common regulatory motif in early development

  4. maternal Nanog (show NANOG Antibodies), Pou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Antibodies)-430 expression

  5. thses data position Pou5f1 and SOX (show PIPOX Antibodies)-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control.

  6. The defects due to HEP induction were rescued by introducing wild-type pou2 mRNA before the heat treatments.

  7. Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.

  8. Pou2 functions in multiple aspects of vertebrate development, especially in the binary decision of the mesendoderm to mesoderm and endoderm in different ways depending on the developmental stage.

  9. show that Pou5f1 binds to phylogenetically conserved Oct (show Plxna2 Antibodies)/Pou5f1 sites in the vox promoter, both in vivo and in vitro

  10. The temporospatial structure of the zebrafish Pou5f1 target networks may explain aspects of the evolution of the mammalian stem cell networks.

OCT4 (POU5F1) Antigen Profile

Antigen Summary

This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6\;22)(p21\;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Alternative names and synonyms associated with OCT4 (POU5F1)

  • POU class 5 homeobox 1 (POU5F1) antibody
  • POU class 5 homeobox 1 (Pou5f1) antibody
  • POU domain, class 5, transcription factor 1 (Pou5f1) antibody
  • POU domain, class 5, transcription factor 3 (pou5f3) antibody
  • cb197 antibody
  • chunp6868 antibody
  • gp-9 antibody
  • gp9 antibody
  • NF-A3 antibody
  • Oct-3 antibody
  • Oct-3/4 antibody
  • Oct-4 antibody
  • Oct3 antibody
  • Oct3/4 antibody
  • oct4 antibody
  • Otf-3 antibody
  • Otf-4 antibody
  • Otf3 antibody
  • Otf3-rs7 antibody
  • Otf3g antibody
  • Otf4 antibody
  • POU-2 antibody
  • pou2 antibody
  • POU5F1 antibody
  • POU5F1L antibody
  • spg/pou2 antibody
  • wu:fd18d06 antibody

Protein level used designations for POU5F1

POU class 5 homeobox 1 , POU domain, class 5, transcription factor 1-like , POU domain class 5 transcription factor 1 , POU domain, class 5, transcription factor 1 , POU domain transcription factor OCT4 , POU-type homeodomain-containing DNA-binding protein , octamer-binding protein 3 , octamer-binding protein 4 , octamer-binding transcription factor 3 , octamer-binding transcription factor-3 , OTF-3 , oct-3 , Octamer-binding transcription factor 3 , oct-4 , octamer binding transcription factor 4 , spg , etID49452.21 , POU domain gene 2 , spiel ohne grenzen , spiel-ohne-grenzen , spiel ohne grenzen/pou2 , spiel-ohne-grenzen/pou2

735657 Pan troglodytes
100091458 Ornithorhynchus anatinus
100174788 Felis catus
100271853 Ornithorhynchus anatinus
100271854 Monodelphis domestica
100302349 Ovis aries
5460 Homo sapiens
481709 Canis lupus familiaris
100127461 Sus scrofa
282316 Bos taurus
100101567 Oryctolagus cuniculus
294562 Rattus norvegicus
714760 Macaca mulatta
744263 Pan troglodytes
18999 Mus musculus
30333 Danio rerio
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