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This study identifies Rif1 as the molecular link between nuclear architecture and replication-timing establishment in mammals.
Oct4 (show POU5F1 ELISA Kits) recruits Smad3 (show SMAD3 ELISA Kits) to bind to Rif1 promoter, but Smad3 (show SMAD3 ELISA Kits) joining facilitates the loading of a polycomb (show CBX2 ELISA Kits) complex that generates a repressive epigenetic modification on Rif1 promoter and maintains the expression of Rif1 in embryonic stem cells.
structural study of the mammalian Rif1
Rif1 negatively modulates Zscan4 expression by maintaining H3K9me3 levels at subtelomeric regions. Rif1 interacts and stabilizes H3K9 methylation complex.
Study concludes that 53BP1 (show TP53BP1 ELISA Kits) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (show PAXIP1 ELISA Kits).
Rif1(-/-) mice are severely compromised for 53BP1-dependent class switch recombination (CSR) and fusion of dysfunctional telomeres.
data establish Rif1 as an important contributor to the control of double-strand break repair by 53BP1 (show TP53BP1 ELISA Kits)
study identifies Rif1 as an ATM (show ATM ELISA Kits) phosphorylation-dependent interactor of 53BP1 (show TP53BP1 ELISA Kits) and shows that absence of Rif1 results in 5'-3' DNA-end resection; Rif1 deficiency impairs DNA repair in cell cycle G(1) and S phases, interferes with immunoglobulin class switchnig and leads to accumulation of chromosome double strand breaks
Rif1 is a key regulator of the replication-timing programme in mammalian cells
Data indicate that Insl6 (show INSL6 ELISA Kits) is an injury-regulated myokine that functions as a myogenic regenerative factor.
In pancreatic cancer cells, RIF1 (show INSL6 ELISA Kits) gene expression in the stem cell-positive cell line was 256 times that seen in the stem cell-negative cell line. RIF1 (show INSL6 ELISA Kits) may be one of the genes that plays an important role in the diagnoses and therapeutic treatment of pancreatic cancer
These data reveal a thus far unrecognized function for Rif1 (show INSL6 ELISA Kits) in the resolution of ultrafine DNA bridges during anaphase to protect genomic integrity.
RIF1 (show INSL6 ELISA Kits) is an important component in DNA damage response signaling. [Review]
RIF1 not only acts downstream of 53BP1 and counteracts BRCA1-mediated end resection but also has a secondary role in promoting BLM function in DNA repair.
RIF1 (show INSL6 ELISA Kits) as the critical effector of 53BP1 (show TP53BP1 ELISA Kits) during DSB repair
Rif1 (show INSL6 ELISA Kits) plays crucial roles in determining the replication timing domain structures in human cells through regulating higher-order chromatin architecture
Rif1 (show INSL6 ELISA Kits) functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred.
High RIF1 (show INSL6 ELISA Kits) expression is associated with breast tumors.
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.
insulin-like peptide 6
, insulin-like peptide INSL6
, relaxin/insulin-like factor 1
, RAP1 interacting factor homolog (yeast)
, telomere-associated protein RIF1
, telomere-associated protein RIF1-like
, rap1-interacting factor 1 homolog
, RAP1 interacting factor 1
, Rap1 interacting factor 1 homolog