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our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease.
Trnsgenic mice overexpressing chicken Ski (c-Ski) have marked decrease in adipose mass with skeletal muscle hypertrophy Results suggest Ski plays a major role in skeletal muscle metabolism and adipogenesis and hence influences risk of obesity and diabetes
After Qingyi Huaji treatment, Ski expression was reduced and pancreatic tumor growth slowed down significantly.
Satb2 (show SATB2 Proteins) recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex.
Data on expression of Ski suggest that Ski is involved in follicular development, oogenesis, ovulation, and luteinization. During the estrous cycle, Ski expression was apparent at proestrus and estrus, faint at metestrus, highest at diestrus.
The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability
Ski regulates several genetic programs and signalling pathways that regulate skeletal muscle and adipose mass to influence body composition development, suggesting that Ski may have a role in risk for obesity and metabolic disease.
Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice
SnoN (show SKIL Proteins) and Ski proteins are up-regulated during liver regeneration
c-Jun (show JUN Proteins) associates with the oncoprotein Ski and suppresses Smad2 (show SMAD2 Proteins) transcriptional activity
Study identified Ski as a functional tumor suppressor with frequent epigenetic inactivation in lung cancer.
Transforming Growth Factor beta inhibitor peptide P144 downregulates SKI and an upregulates SMAD7 (show SMAD7 Proteins) at both transcriptional and translational levels in glioblastoma cell lines.
miR (show MLXIP Proteins)-1908 had a positive role in scar formation by suppressing Ski-mediated inflammation and fibroblast proliferation in vitro and in vivo.
Overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA (show AURKA Proteins).
our findings suggest that Ski represses TGF-b-induced EMT (show ITK Proteins) and invasion by inhibiting SMAD (show SMAD1 Proteins)-dependent signaling in non-small cell lung cancer
Ski regulates Hippo and TAZ (show TAZ Proteins) signaling to suppress breast cancer progression.
Eight recurrent and three novel SKI mutations from eleven SGS (show FBN1 Proteins) patients were located in the R-SMAD (show SMAD1 Proteins) binding domain, except for one in the DHD domain.
acetaldehyde up-regulates COL1A2 (show COL1A2 Proteins) by modulating the role of Ski and the expression of SMADs 3, 4, and 7.
c-Ski is an important regulator in the activation of CAFs and may serve as a potential therapeutic target to block breast cancer progression.
Ski expression is a novel negative feedback mechanism acting on retinoic acid signaling
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation.
v-ski sarcoma viral oncogene homolog (avian)
, avian sarcoma viral (v-ski) oncogene homolog natural resistance-associated macrophage protein 1
, v-ski avian sarcoma viral oncogene-like protein
, proto-oncogene c-Ski
, ski oncogene
, Sloan-Kettering viral oncogene homolog
, superkiller viralicidic activity 2-like
, v-ski sarcoma viral oncogene homolog
, ski oncoprotein
, ski sarcoma viral oncogene homolog