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Data show that interplay of Smad1/5 and MAP kinase (show MAPK1 ELISA Kits) signaling system (ERK (show MAPK1 ELISA Kits) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (show SMAD9 ELISA Kits) act redundantly to each other downstream of smad5 (show SMAD5 ELISA Kits) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (show SMAD5 ELISA Kits).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 retrotransposon contains the MAD protein (show MXD1 ELISA Kits) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (show GRIN2A ELISA Kits) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (show TGFb ELISA Kits) and Wnt (show WNT4 ELISA Kits) pathways depending on its phosphorylation state.
Yorkie (show YAP1 ELISA Kits) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (show TGFb ELISA Kits) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (show SRC ELISA Kits) and ERK1/2 (show MAPK1/3 ELISA Kits) inhibitors or by the knockdown of Smad1 (show GARS ELISA Kits).
Low doses of IL1B (show IL1B ELISA Kits) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (show IL1B ELISA Kits) inhibit BMP/Smad signaling through the activation of NF-kappaB (show NFKB1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (show GARS ELISA Kits) signaling pathway and inhibits Col (show HDAC1 ELISA Kits) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 ELISA Kits) and both zeta-chain-associated protein kinase (show CDK7 ELISA Kits) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (show SMAD2 ELISA Kits)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS ELISA Kits)/8 and lower SMAD-4 (show SMAD4 ELISA Kits) expression in chronic lymphocytic leukemia cells
melatonin treatment was found to downregulate TNFalpha (show TNF ELISA Kits)-induced SMURF1 (show SMURF1 ELISA Kits) expression and then decrease SMURF1 (show SMURF1 ELISA Kits)-mediated ubiquitination and degradation of SMAD1 (show GARS ELISA Kits) protein
The expression of specific targets Smad1 (show GARS ELISA Kits) and Osterix (show SP7 ELISA Kits) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 ELISA Kits)+). As miR (show MLXIP ELISA Kits)-30b, miR (show MLXIP ELISA Kits)-133a, and miR (show MLXIP ELISA Kits)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 ELISA Kits)+) with a congruent modulation of their known targets Runx2 (show RUNX2 ELISA Kits), Smad1 (show GARS ELISA Kits), and Osterix (show SP7 ELISA Kits), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
the BMP-2 (show BMP2 ELISA Kits)/Smad1 (show GARS ELISA Kits)/5/RUNX2 (show RUNX2 ELISA Kits) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP ELISA Kits) synth
Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (show GARS ELISA Kits).
The expression SMAD1 (show GARS ELISA Kits) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).
Overexpression of Smad1 (show GARS ELISA Kits) is associated with prostate cancer.
We discovered that Smad1/5/4-Amhr2 (show AMHR2 ELISA Kits)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (show AMHR2 ELISA Kits)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (show TGFB1 ELISA Kits)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (show YAP1 ELISA Kits) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (show BMP2 ELISA Kits)-YAP (show YAP1 ELISA Kits)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
Dynamin (show DNM1 ELISA Kits)-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2 (show BMP2 ELISA Kits)) and its receptors is dispensable for the initiation of Smad signaling
Thyroid-specific Smad1 and Smad5 (show SMAD5 ELISA Kits) double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 and Smad5 (show SMAD5 ELISA Kits) have overlapping functions to govern hepcidin (show HAMP ELISA Kits) transcription. Moreover, erythropoietin (show EPO ELISA Kits) and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin (show HAMP ELISA Kits) expression.
Actin cytoskeleton depolymerization inhibites BMP2 (show BMP2 ELISA Kits) signaling via blocking of Smad by dephosphorylated CNN1 (show CNN1 ELISA Kits) in osteoblast cells under simulated microgravity.
Store operated calcium entry negatively regulates the Smad1 signaling pathway and inhibits Col (show HDAC1 ELISA Kits) IV protein production in glomerular mesangial cells.
Thus, our findings identify an unrecognized function of neogenin (show NEO1 ELISA Kits) in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2 (show BMP2 ELISA Kits)-neogenin (show NEO1 ELISA Kits)-YAP (show YAP1 ELISA Kits)-Smad1, underlying astrogliogenesis in developing mouse neocortex.
Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta (show TGFB1 ELISA Kits)-SMAD signaling pathway.
interactions between miR (show MYLIP ELISA Kits)-26 and the Smad1 3'UTR (show UTS2R ELISA Kits) modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (show TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (show SMAD2 ELISA Kits)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 ELISA Kits).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1