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Browse our SMAD, Mothers Against DPP Homolog 1 Proteins (SMAD1)

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SMAD, Mothers Against DPP Homolog 1 Proteins (SMAD1)
On are 22 SMAD, Mothers Against DPP Homolog 1 (SMAD1) Proteins from 9 different suppliers available. Additionally we are shipping SMAD, Mothers Against DPP Homolog 1 Antibodies (333) and SMAD, Mothers Against DPP Homolog 1 Kits (49) and many more products for this protein. A total of 423 SMAD, Mothers Against DPP Homolog 1 products are currently listed.
2/23, AI528653, apg, BSP-1, BSP1, c28, CG12399, dMad, Dmel\\CG12399, E(zen)2, En(vvl), fb39h09, JV4-1, JV41, l(2)k00237, mad, Madh1, Madr1, Mat, MLP, Mlp1, MusMLP, p-Mad, pMad, pSmad, Smad, smad-1, smad1, wu:fb39h09, wu:fb97e04, xmad, Xmad1, Xsmad1
list all proteins Gene Name GeneID UniProt
SMAD1 4086 Q15797
SMAD1 17125 P70340
SMAD1 25671  

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SMAD, Mothers Against DPP Homolog 1 Proteins (SMAD1) by Origin

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Top referenced SMAD, Mothers Against DPP Homolog 1 Proteins

  1. Human SMAD1 Protein expressed in Wheat germ - ABIN1320591 : Andrews, Schneider, Yang, Michaels, Chen, Tang, Emkey: Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays. in Assay and drug development technologies 2010 (PubMed)
    Show all 2 references for ABIN1320591

More Proteins for SMAD, Mothers Against DPP Homolog 1 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. Data show that interplay of Smad1/5 and MAP kinase (show MAPK1 Proteins) signaling system (ERK (show MAPK1 Proteins) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  2. this study uncovers that smad1 and smad9 (show SMAD9 Proteins) act redundantly to each other downstream of smad5 (show SMAD5 Proteins) to mediate ventral specification and to regulate embryonic myelopoiesis.

  3. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (show SMAD5 Proteins).

Fruit Fly (Drosophila melanogaster) SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.

  2. Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.

  3. During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (show GRIN2A Proteins) receptors at neuromuscular junction synapses.

  4. The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.

  5. Mad has distinct signal transduction roles in the BMP (show TGFb Proteins) and Wnt (show WNT4 Proteins) pathways depending on its phosphorylation state.

  6. Yorkie (show YAP1 Proteins) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.

  7. Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.

  8. importin (show KPNA4 Proteins)-beta11 function interacts with the bone morphogenic protein (show TGFb Proteins) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function

  9. Mad depletion or overexpression produced Wingless-like embryonic segmentation phenotypes

  10. The downstream transcription factor Mothers against dpp is essential for the normal structural and functional development of the Drosophila neuromuscular junction, a synapse that displays activity-dependent plasticity.

Human SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Proteins) and both zeta-chain-associated protein kinase (show CDK7 Proteins) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (show SMAD2 Proteins)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Proteins)/8 and lower SMAD-4 (show SMAD4 Proteins) expression in chronic lymphocytic leukemia cells

  2. melatonin treatment was found to downregulate TNFalpha (show TNF Proteins)-induced SMURF1 (show SMURF1 Proteins) expression and then decrease SMURF1 (show SMURF1 Proteins)-mediated ubiquitination and degradation of SMAD1 (show GARS Proteins) protein

  3. The expression of specific targets Smad1 (show GARS Proteins) and Osterix (show SP7 Proteins) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Proteins)+). As miR (show MLXIP Proteins)-30b, miR (show MLXIP Proteins)-133a, and miR (show MLXIP Proteins)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Proteins)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Proteins), Smad1 (show GARS Proteins), and Osterix (show SP7 Proteins), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o

  4. the BMP-2 (show BMP2 Proteins)/Smad1 (show GARS Proteins)/5/RUNX2 (show RUNX2 Proteins) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Proteins) synth

  5. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (show GARS Proteins).

  6. The expression SMAD1 (show GARS Proteins) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).

  7. Overexpression of Smad1 (show GARS Proteins) is associated with prostate cancer.

  8. SMAD1 (show GARS Proteins) signaling may be a key pathway contributing the pathogenesis of Cardio-facio-cutaneous syndrome during early development.

  9. Smad1 (show GARS Proteins) elevation serves as a compensatory mechanism for p53 (show TP53 Proteins) deficiency by potentiating the activation of p53 (show TP53 Proteins) parallel pathways.

  10. Our data indicated that downregulation of miR (show MLXIP Proteins)-26b in osteosarcoma elevated the levels of CTGF (show CTGF Proteins) and Smad1 (show GARS Proteins), facilitating osteosarcoma metastasis

Mouse (Murine) SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. BetA can enhance in vivo osteogenic potentials of BMP2 (show BMP2 Proteins), possibly via stimulating Smad 1/5/8 and p38 (show CRK Proteins) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

  2. Mutant GDF5 (show GDF5 Proteins) enhances ameloblast differentiation via accelerated BMP2 (show BMP2 Proteins)-induced Smad1-Smad5 (show SMAD5 Proteins)-Smad8 (show SMAD9 Proteins) phosphorylation.

  3. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1.

  4. Data show that in R-Smad proteins Smad1;Smad5 (show SMAD5 Proteins) knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD signaling is dispensable for self-renewal.

  5. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  6. AHNAK (show AHNAK Proteins) plays a crucial role in body fat accumulation by regulating adipose tissue development via interaction with the SMAD1 protein and can be involved in metabolic homeostasis

  7. Results show that Smad1-deficient mice exhibit enhanced neuronal survival and improved neurological recovery at 7 days after transient middle cerebral artery occlusion suggesting that Smad1-mediated signal pathway is involved in stroke pathophysiology.

  8. The study reveals a novel miR (show MLXIP Proteins)-26a-GSK3beta-Smad1 signaling pathway in the regulation of mammalian axon regeneration.

  9. Nondiabetic Smad1-Tg had normal kidney however, diabetes resulted in mesangial expansion, consistent with an increase in glomerular phosphorylated Smad1. Heterozygous Smad1 KO mice exhibit attenuated mesangial expansion in the diabetic condition.

  10. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (show BMP2 Proteins)/Smad1/5/8 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.

Xenopus laevis SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. interactions between miR (show MYLIP Proteins)-26 and the Smad1 3'UTR modulate Smad1 function in the establishment of axial patterning.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 1 (SMAD1) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD, Mothers Against DPP Homolog 1 (SMAD1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with SMAD, Mothers Against DPP Homolog 1 (SMAD1)

  • SMAD family member 1 (smad1)
  • SMAD family member 1 (SMAD1)
  • MAD homolog 1 (Drosophila) (smad1)
  • Mothers against dpp (Mad)
  • SMAD family member 1 (Smad1)
  • SMAD family member 1 (smad1-a)
  • 2/23 protein
  • AI528653 protein
  • apg protein
  • BSP-1 protein
  • BSP1 protein
  • c28 protein
  • CG12399 protein
  • dMad protein
  • Dmel\\CG12399 protein
  • E(zen)2 protein
  • En(vvl) protein
  • fb39h09 protein
  • JV4-1 protein
  • JV41 protein
  • l(2)k00237 protein
  • mad protein
  • Madh1 protein
  • Madr1 protein
  • Mat protein
  • MLP protein
  • Mlp1 protein
  • MusMLP protein
  • p-Mad protein
  • pMad protein
  • pSmad protein
  • Smad protein
  • smad-1 protein
  • smad1 protein
  • wu:fb39h09 protein
  • wu:fb97e04 protein
  • xmad protein
  • Xmad1 protein
  • Xsmad1 protein

Protein level used designations for SMAD1

MAD homolog 1 , SMAD, mothers against DPP homolog 1 , mothers against decapentaplegic homolog 1 , mothers against decapentaplegic-like protein 1 , MAD (mothers against decapentaplegic, Drosophila) homolog 1 , SMA- and MAD-related protein 1 , SMAD 1 , SMAD family member 1 , mothers against DPP homolog 1 , CG12399-PA , CG12399-PB , Mad-PA , Mad-PB , apang , mother against decapentaplegic , mothers against decapentaplegi , mothers against decapentaplegic , mothers against dpp , phospho-Smad , phosphoSmad , phosphorylated smad , MAD, mothers against decapentaplegic homolog 1 , Mad-related protein 1 , TGF-beta signaling protein 1 , transforming growth factor-beta signaling protein 1 , transforming growth factor-beta-signaling protein 1 , Smad 1 , dwarfin-A , dwf-A , mMad1 , mad-related protein 1 , mothers-against-DPP-related 1 , MAD homolog1 (mothers against decapentaplegic, Drosophila) , mothers against DPP , BMP pathway effector , BMP signal transducer Smad1 , Sma- and Mad-related protein 1

493211 Xenopus (Silurana) tropicalis
574340 Macaca mulatta
30628 Danio rerio
33529 Drosophila melanogaster
4086 Homo sapiens
17125 Mus musculus
25671 Rattus norvegicus
379664 Xenopus laevis
395680 Gallus gallus
475456 Canis lupus familiaris
397016 Sus scrofa
540488 Bos taurus
450142 Pan troglodytes
100432108 Pongo abelii
100033850 Equus caballus
443229 Ovis aries
100341544 Oryctolagus cuniculus
100727257 Cavia porcellus
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