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Human Polyclonal STAG2 Primary Antibody for ICC, IF - ABIN151766
Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008
Show all 7 Pubmed References
Human Polyclonal STAG2 Primary Antibody for ELISA, IHC - ABIN4356174
Lara-Pezzi, Pezzi, Prieto, Barthelemy, Carreiro, Martínez, Maldonado-Rodríguez, López-Cabrera, Barbero: Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3. in The Journal of biological chemistry 2004
Human Polyclonal STAG2 Primary Antibody for ELISA, WB - ABIN4356175
Hauf, Roitinger, Koch, Dittrich, Mechtler, Peters: Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. in PLoS biology 2005
Human Polyclonal STAG2 Primary Antibody for ICC, IF - ABIN151767
Zhang, Pati: C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. in Cell cycle (Georgetown, Tex.) 2015
Extending the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by extending the period during which tumor-driving mutations occur.
Loss of STAG2 or STAG3 (show STAG3 Antibodies), which encode subunits of the cohesin complex (show SMC3 Antibodies), in melanoma cells results in resistance to BRAF (show BRAF Antibodies) inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 (show STAG3 Antibodies) proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines.
the clinical features of these three cases are remarkably similar to those observed in other well-established cohesinopathies. Herein, we suggest that STAG2 is a dosage-sensitive gene and that heterozygous loss-of-function variants lead to a cohesinopathy.
results indicated that the complete loss of STAG2 expression was predictive for better recurrence-free survival and cancer-specific survival, suggesting its potential value as a prognostic biomarker in bladder cancer
We suggest that increased STAG2 gene copy number and dysregulation of its downstream target genes may be responsible for the specific clinical findings of this syndrome.
Characterization of C-terminal nuclear localization signal of the human SA2 stromalin
Data show a significantly higher stromal antigen 2 (STAG2) mRNA and protein levels in normal bladder cells than bladder cancer cells.
Microduplication of chromosome Xq25 encompassing STAG2 gene in a boy with intellectual disability
STAG2 promotes the correction of kMT (show CAMKMT Antibodies) attachment errors to ensure faithful chromosome segregation during mitosis.
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 (show TP53 Antibodies) mutations
our data suggests that STAG3 (show STAG3 Antibodies) is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis.
STAG3 (show STAG3 Antibodies) is a strong candidate gene for male infertility
STAG3 emerges as the key STAG cohesin involved in major functions of meiotic cohesin.
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
E2F6 (show E2F6 Antibodies) silences SMC1beta (show SMC1B Antibodies) and STAG3 (show STAG3 Antibodies) in somatic cells
a cohesin complex (show SMC3 Antibodies) containing Rad21 (show RAD21 Antibodies) and STAG2 cooperates with a STAG3 (show STAG3 Antibodies)-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis
Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
stromal antigen 2
, stromal antigen 2, isoform 1
, SCC3 homolog 2
, cohesin subunit SA-2
, nuclear protein SA2
, cohesin subunit XSA2
, stromal antigen 2 homolog
, SCC3 homolog 3
, cohesin subunit SA-3
, stromalin 3