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The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA (show DROSHA Proteins) rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 (show ESR1 Proteins) rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR (show MLXIP Proteins)-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase (show TUT1 Proteins)) Zcchc11 (TUT4) activity.
Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
miR (show MLXIP Proteins)-26a directly targets Lin28B (show LIN28B Proteins) and Zcchc11-two critical repressors of let-7 maturation.
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 (show LIN28A Proteins) uses two different TUTases to control let-7 expression .
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity
TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer (show DICER1 Proteins) processing. Knockdown of TUT4 and Lin28 (show LIN28A Proteins) reduces the level of stem cell markers
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (show IL22 Proteins) after LPS (show IRF6 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).
We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 (show IGF1 Proteins) expression and enhancing postnatal growth and survival
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (show TIFA Proteins) after LPS (show TLR4 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).
Zcchc11 fine tunes IL-6 (show IL6 Proteins) production by uridylating miR (show MLXIP Proteins)-26a.
Lin28 (show LIN28A Proteins) recruits the TUTase (show TUT1 Proteins) Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
ZCCHC11 is an RNA uridyltransferase (EC 126.96.36.199) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009
zinc finger, CCHC domain containing 11
, Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1)-like
, terminal uridylyltransferase 4-like
, Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
, Est1p-like protein B
, protein SMG5
, SMG5 homolog nonsense mediated mRNA decay factor
, terminal uridylyltransferase 4
, PAP associated domain containing 3
, TUTase 4
, zinc finger CCHC domain-containing protein 11