Browse our COMT (COMT) ELISA Kits

Full name:
Catechol-O-Methyltransferase ELISA Kits (COMT)
On www.antibodies-online.com are 39 Catechol-O-Methyltransferase (COMT) ELISA Kits from 11 different suppliers available. Additionally we are shipping COMT Antibodies (180) and COMT Proteins (27) and many more products for this protein. A total of 258 COMT products are currently listed.
Synonyms:
comt, Comt1, D16Wsu103e, D330014B15Rik, mb-comt, MGC154444, s-comt

Top referenced COMT ELISA Kits

  1. Human COMT ELISA Kit for Sandwich ELISA - ABIN481734 : Karpeta, Warzecha, Jerzak, Ptak, Gregoraszczuk: Activation of the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism by 2,2',4,4'-tetrabromodiphenyl ether (BDE47) in the pig ovary. in Reproductive toxicology (Elmsford, N.Y.) 2012 (PubMed)

More ELISA Kits for COMT Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. Association between COMT genotype and 6-m walk time: Those with higher (Val/Val) and lower (Met/Met) dopamine slowed more over 10 years than those with the intermediate (Met/Val) dopamine. Race differences seen.

  2. This paired case-control study examined the association between COMT gene rs4680 polymorphism and suicide attempts. The G/G genotype was significantly more prevalent in female suicide attempters than their matched controls. Conditional logistic regression showed that the G/G genotype was significantly associated with an increased risk of suicide attempts only for women (odds ratio=2.3; 95% confidence interval: 1.2-4.2)

  3. We report that the variation in gene sequence at the four COMT SNPs studied was not associated with an altered the risk of schizophrenia but genotype at rs4680 and rs4818, but not rs165519 and rs737865, were associated with varying levels of cortical CHRM1 (show CHRM1 ELISA Kits) expression in the human dorsolateral prefrontal cortex. These data are the first to suggest that levels of CHRM1 (show CHRM1 ELISA Kits) in the human DLPFC are, in part, determined by COMT seq

  4. Study is the first to demonstrate the influence of a functional and behaviorally relevant genetic variant (val158 met polymorphism on the catechol-O-methyltransferase gene) on connectome-wide functional connectivity and is an important step toward establishing the functional connectome as an endophenotype for psychiatric and behavioral phenotypes.

  5. This study found a significant interaction between rs4680 in COMT and rs4986936 in ESR1 (show ESR1 ELISA Kits) (P = .007) on opioid consumption.

  6. No direct correlation between catechol-O-methyltransferase (COMT) activity and rs4680 genotypes was found in patients with bipolar disorder; however, the severity of manic symptoms was highly correlated with COMT activity in the striatum, irrespective of the diagnostic group.

  7. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males). A significant three-way interaction was found, after correction for multiple testing, between COMT genotype, exposure to violence, and parent-child relationship in association with physical but not verbal aggressive behavior.

  8. We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (show DRD3 ELISA Kits) (P = 0.032), DRD4 (show DRD4 ELISA Kits) (P = 0.05), MB-COMT (P = 0.009), and AKT1 (show AKT1 ELISA Kits) (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively)

  9. Bipolar patients: haplotypes of COMT are associated with age at onset and clinical evolution

  10. Lower catechol-O-methyltransferase (COMT) enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. COMT haploinsufficiency, DA dysfunction, and white matter abnormalities may contribute toward the presence of neurological soft signs in 22q11DS. [review]

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.

  2. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP ELISA Kits)) and postero-parieto-temporal cortex of male, but not female adult mice.

  3. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  4. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  5. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 ELISA Kits).

  6. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  7. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  8. COMT knockout mice were more impulsive compared with wild-type littermates.

  9. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  10. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

COMT Antigen Profile

Antigen Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Alternative names and synonyms associated with COMT

  • catechol-O-methyltransferase (COMT) Elisa Kit
  • catechol-O-methyltransferase (comt) Elisa Kit
  • catechol-O-methyltransferase (comt.2) Elisa Kit
  • catechol-o-methyltransferase (Rv1703c) Elisa Kit
  • catechol-o-methyltransferase (Mb1729c) Elisa Kit
  • catechol O-methyltransferase-like (LOC100630273) Elisa Kit
  • catechol-O-methyltransferase (Comt) Elisa Kit
  • comt Elisa Kit
  • Comt1 Elisa Kit
  • D16Wsu103e Elisa Kit
  • D330014B15Rik Elisa Kit
  • mb-comt Elisa Kit
  • MGC154444 Elisa Kit
  • s-comt Elisa Kit

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

GENE ID SPECIES
416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
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