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Significant associations have been found between CpG sites and patient sex, including DNA methylation (show HELLS ELISA Kits) in CASP6 (show CASP6 ELISA Kits), a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone.
These evidences were suggestive of a 46,XY DSD (show FADS1 ELISA Kits) due to 17betaHSD3 deficiency. An homozygous mutation (IVS3 -1 G>C or c.326-1G>C) of the 17betaHSD3 gene was discovered.
HSD17B12 overexpression is shown to be a marker of poor survival in patients with ovarian cancer; expression in the tumor and function of this enzyme facilitates ovarian cancer progression.
High HSD17B12 expression is associated with neoplasms.
17beta-HSD12 is the major estrogenic 17beta-HSD (show HSD17B3 ELISA Kits) responsible for the conversion of E1 to E2 in women.
Location of 17beta-hydroxysteroid dehydrogenase (show HSD17B7 ELISA Kits) type 12 through the human body.
determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD (show HSD17B3 ELISA Kits) in preadipocytes before and after differentiation into mature adipocytes
There is no difference in catalytic properties between variants of 17beta-HSD (show HSD17B3 ELISA Kits) types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD (show HSD17B3 ELISA Kits) type 5 showed a slightly decreased activity.
SREBP-1 (show SREBF1 ELISA Kits) represents one of the transcriptional regulators of human 17beta-HSD12.
Hsd17b12 is essential for mouse organogenesis and embryonic survival.
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.
, 17-beta-hydroxysteroid dehydrogenase 12
, 17beta-HSD type 12
, 3-ketoacyl-CoA reductase
, estradiol 17-beta-dehydrogenase 12
, short chain dehydrogenase/reductase family 12C, member 1
, steroid dehydrogenase homolog
, smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3
, steroid dehydrogenase
, hydroxysteroid (17-beta) dehydrogenase 12
, 17-beta-HSD 12-A
, 17-beta-hydroxysteroid dehydrogenase 12-A
, estradiol 17-beta-dehydrogenase 12-A