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UGT1A10 exhibited somewhat higher BPA (show DST Antibodies) glucuronidation activity than UGT1A9 (show UGT1A9 Antibodies), but it was lower than UGT2A1 (show UGT2A1 Antibodies) and UGT2B15 (show UGT2B15 Antibodies). 4.
In further studies with UGT1A10, mutant F93G exhibited increased glucuronidation rates of 16alpha-hydroxyestrone, but not estrone
A graphene nanocage with regulatable space for the assembly of a CYP1A2 (show CYP1A2 Antibodies)-UGT1A10 bienzyme complex has been constructed via a click reaction, and used to study drug sequential metabolism using an electrochemically-driven method.
DNA hypermethylation results in defective expression of UGT1A10 in the liver.
Suggest that extrahepatic UGT1A10 plays an important role in the metabolism and the bioactivation of the antitumor agent C-1305.
Data suggest that darexaban glucuronidation in jejunum microsomes is mainly catalyzed by UGT1A10; studies include kinetics of recombinant UGT (show SLC35A2 Antibodies) proteins, liver microsomes, and jejunal microsomes (and UGT (show SLC35A2 Antibodies) isoform-specific inhibitors/substrates).
role of Phenylalanine 93 in UGT1A10
The results also indicated that UGT1A1 (show UGT1A1 Antibodies), UGT1A7 (show UGT1A7 Antibodies), UGT1A8, UGT1A9 (show UGT1A9 Antibodies), UGT1A10 and UGT2B7 (show UGT2B7 Antibodies) are the most important six UGT (show SLC35A2 Antibodies) isoforms for metabolizing the three dihydroxyflavones and seven monohydroxyflavones.
it appears that residues within segment C of the N-terminal domain, mainly at positions 152 and 169, contribute to the higher glucuronidation rates of UGT1A10
Data suggest that UGT1A10 is important in detoxification of the carcinogen NNAL and that polymorphisms in UGT1A10 promoter (and thus altered gene expression) may be important in susceptibility to hepatocellular carcinoma.
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
UDP glycosyltransferase 1 family, polypeptide A10
, UDP-glucuronosyltransferase 1-10
, UDP-glucuronosyltransferase 1-J
, UDP-glucuronosyltransferase 1A10
, UDPGT 1-10
, UDP glycosyltransferase 1 family polypeptide A13
, UDP glucuronosyltransferase 1 family, polypeptide A10
, UDP-glucuronosyltransferase 1-7C
, UDP-glucuronosyltransferase 1A7C
, UDPGT 1-7C