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Human UGT2B15 Protein expressed in HEK-293 Cells - ABIN2734994
Divakaran, Hines, McCarver: Human hepatic UGT2B15 developmental expression. in Toxicological sciences : an official journal of the Society of Toxicology 2014
This study showed that UGT2B7 (show UGT2B7 Proteins) and UGT2B15 3'-UTRs contain miRNA response elements for multiple miRNAs that may contribute to variable drug glucuronidation.
Results found no significant increased risk for benign prostatic hyperplasia (BPH) in men with low activity genotype at D85Y, but found rather, a significant association between UGT2B15 D85Y and BPH risk when it is in combination with the UGT2B17 copy number variation.
Our findings highlight the influence of UGTT1A4 haplotypes on tamoxifen disposition in Asian breast cancer patients, while genetic variants in UGT2B7 (show UGT2B7 Proteins) and UGT2B15 appear to be of minor importance.
the UGT2B15 and UGT2B17 enzymes are transcriptionally regulated by sex hormone signaling in ERalpha (show ESR1 Proteins)+ breast cancer cells and are highly expressed in a subset of primary breast cancers.
UGT2B15 genotype contributes to postoperative anxiety reduction after lorazepam premedication.
Report frequency of UGT2B15 genetic polymorphisms in Pakistani population and genotype/phenotype correlation for glucuronidation of paracetamol.
CYP3A4 (show CYP3A4 Proteins), CYP3A7 (show CYP3A7 Proteins), UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli.
This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4 (show UGT1A4 Proteins), UGT2B7 (show UGT2B7 Proteins), UGT2B15 and UGT2B17 in 132 patients with estrogen receptor (show ESR1 Proteins)-positive breast cancer under treatment with tamoxifen
miR (show MLXIP Proteins)-376c is inversely linked to UGT2B15 and UGT2B17 expression in high-grade prostate cancer and metastasis.UGT2B15 and UGT2B17 genes are direct targets of miR (show MLXIP Proteins)-376c and thus may influence steroid metabolism during prostate cancer progression.
Data suggest that both 17beta-estradiol and the antiestrogen 4-OHTAM (4-hydroxytamoxifen, a metabolite of tamoxifen and substrate of UGT2B15) up-regulate UGT2B15 in breast cancer cells via the same estrogen receptor alpha (show ESR1 Proteins)- (ERa-)signaling pathway.
This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B15
, UDP glucuronosyltransferase 2 family, polypeptide B4
, UDP glucuronosyltransferase 2 family, polypeptide B17-like
, UDP glycosyltransferase 2B15
, UDP-glucuronosyltransferase 2B15
, UDP-glucuronosyltransferase 2B8
, UDP-glucuronosyltransferase UGT2B15
, UDP-glucuronyltransferase, family 2, beta-15
, UDPGT 2B15
, UDP glucuronosyltransferase 2 family, polypeptide B36
, UDP glycosyltransferase 2 family, polypeptide B4
, UDP-glucuronosyltransferase 2B12
, UDP-glucuronosyltransferase 2B36
, UDP-glucuronosyltransferase 2B4
, UDPGT 2B12
, UDPGT 2B36
, UDPGT 2B4