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The androgen-inactivating UGT2B28 enzyme influences hormone levels, clinical and pathologic factors, and the risk of prostate cancer progression.
UGT2B28 was clearly detected in breast and adipose tissue; GT2B28 expression in the breast was comparatively low, about 1.6% of GAPDH (show GAPDH ELISA Kits) mRNA levels, and was less than 5% of normalized (against GAPDH (show GAPDH ELISA Kits)) UGT2B7 (show UGT2B7 ELISA Kits) and 2B10 mRNA expression levels in the liver
Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B28
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP-glucuronosyltransferase 2B28
, UDPGT 2B28
, UDP glucuronosyltransferase 2 family, polypeptide B11