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Human Polyclonal UGT2B4 Primary Antibody for WB - ABIN1881977
Lévesque, Ménard, Laverdière, Bellemare, Barbier, Girard, Guillemette: Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation. in Pharmacogenetics and genomics 2010
Show all 3 Pubmed References
UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
These data indicate that knocking down PAPSS (show PAPSS1 Antibodies) increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 (show SULT2A1 Antibodies) activity
Methadone inhibits CYP2D6 (show CYP2D6 Antibodies) and UGT2B7 (show UGT2B7 Antibodies)/2B4 (show CD244 Antibodies) in vivo
The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.
The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection.
Extensive splicing of transcripts of the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.
Farnesoid X receptor (show xpr1 Antibodies) (FXR (show NR1H4 Antibodies)) induces the UGT2B4 enzyme in hepatocytes; this study identifies UGT2B4 as a novel FXR (show NR1H4 Antibodies) target gene.
UGT2B4 expression is regulated by PPARalpha (show PPARA Antibodies)
P.1053: "...UGT2B4...is...fairly common in Caucasians...and Africans..."but...still rare in ...Japanese..." P.1054: "...genotyping UGT2B4...in Japanese...would be useful for studies on... association between haplotypes and pharmacokinetic...parameters."
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
UDP glucuronosyltransferase 2B4
, UDP-glucuronosyltransferase 2B4
, UDP-glucuronyltransferase, family 2, beta-4
, UDPGT 2B4
, hyodeoxycholic acid
, hyodeoxycholic acid-specific UDPGT
, UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B15
, UDP glucuronosyltransferase 2B10
, UDP glucuronosyltransferase 2 family, polypeptide B4
, UDP glucuronosyltransferase 2 family, polypeptide B7
, UDP glucuronosyltransferase 2 family, polypeptide B17-like
, UDP glucuronosyltransferase 2 family, polypeptide B17