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We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
This study identifies a novel regulatory crosstalk between Ral (show rala Proteins) and Arf6 that controls Ral (show rala Proteins) function in cells.
ARHGAP24 (show ARHGAP24 Proteins) may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
ARF6 was a downstream target of Kras/ERK (show EPHB2 Proteins) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (show F3 Proteins) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (show RAB35 Proteins) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
Data suggest that activated ARF6 controls GNAQ (show GNAQ Proteins) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
expression and activation of LHCGR (show LHCGR Proteins) and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR (show LHCGR Proteins) internalization is unaltered
The Squamous cell carcinoma of the tongue cell line SCC (show CYP11A1 Proteins)-9, which overexpress Arf6 and AMAP1 (show ASAP1 Proteins), also expressed EPB41L5 (show EPB41L5 Proteins) at high levels to promote invasiveness, whereas the weakly invasive SCC (show CYP11A1 Proteins)-25 cells did not express EPB41L5 (show EPB41L5 Proteins) at notable levels.
The present study demonstrated that the Arf6-specific GAP ACAP3 plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex.
Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3 (show IKBKG Proteins)-dependent trafficking of endosomes containing N-cadherin (show CDH2 Proteins) during cortical layer formation.
The results show that ARNO (show CYTH2 Proteins) interaction with the RLIP76 (show RALBP1 Proteins) N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 (show RALBP1 Proteins) control of Rac (show AKT1 Proteins).
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (show DMD Proteins)-associated glycoprotein complex (DGC (show GGCX Proteins)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (show GGCX Proteins).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor (show ARHGEF12 Proteins)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (show ABCA1 Proteins) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (show ABCA1 Proteins) recycling and efflux of intracellular cholesterol.
These findings suggest that SDCCAG3 (show SDCCAG3 Proteins) might function in endosomal trafficking downstream of Arf6.
both Arf6 activation through GluN2B (show GRIN2B Proteins)-BRAG1 during early development and the transition from BRAG1- to BRAG2 (show IQSEC1 Proteins)-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
PPAR (show PPARA Proteins) expression, the activity of its target gene AOX (show ACOX1 Proteins), and peroxisomal biogenesis are developmentally modulated in zebrafish
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP ribosylation factor III
, ADP-ribosylation factor 6
, peroxisome proliferator-activated receptor gamma