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anti-Human RORA Antibodies:
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Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults.
A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of placental abruption.
In a Han Chinese population, an association between RORA gene variation and depression personality trait was found.
associations between NR1D1 (show NR1D1 Antibodies), RORA and RORB (show RORB Antibodies) genes and bipolar disorder.(
the data presented in this report are that RORA is linked in important ways to molecules that could be playing important roles in the AD etiology.
Retinoic acid receptor-related orphan receptor-alpha (RORalpha) may be a potential risk gene for chronic obstructive pulmonary disease (COPD (show ARCN1 Antibodies)).
RORA variants were associated with dyslipidemia and obesity in Mexicans.
RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A (show SCN1A Antibodies) rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians.
A cluster of RORA SNPs around rs2083074 showed an effect on psychic adverse drug reactions in the bipolar disorder.
RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3 (show SOCS3 Antibodies)-dependent inflammation
This study showed that spontaneous Rora mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
the inhibition of NF-kappaB (show NFKB1 Antibodies) by melatonin, but not that of NLRP3 (show NLRP3 Antibodies), was blunted in RORalpha (sg/sg) mice, indicating that functional RORalpha transcription factor is necessary for the initiation of the innate immune response against inflammation.
Rora induces the mRNA level of antioxidant enzymes, superoxide dismutase 2 (show SOD2 Antibodies) and glutathione peroxidase 1 (show GPX1 Antibodies), through the Rora response elements located in the upstream promoters of Sod2 (show SOD2 Antibodies) and Gpx1 (show GPX1 Antibodies).
The nuclear receptors retinoic acid receptor (show RARA Antibodies)-related orphan receptors-alpha and gammat (RORalpha and RORgammat) play critical roles in the development of TH17 cells.
RORalpha is a transcriptional activator of insulin (show INS Antibodies).
Corl2/Skor2 (show SKOR2 Antibodies) has a role in regulating cerebellar Purkinje cell differentiation in a pathway involving RORalpha
RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1 (show CYP8B1 Antibodies), which regulates bile acid composition and serum and liver cholesterol levels.
This study suggests an autocrine Wnt5a (show WNT5A Antibodies)-Ror signaling pathway that directs sympathetic axon branching during target innervation.
Disruption of Roralpha1 and cholesterol 25-hydroxylase (show CH25H Antibodies) expression attenuates phagocytosis in male Roralphasg/sg mice.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
, nuclear receptor ROR-alpha
, nuclear receptor RZR-alpha
, nuclear receptor subfamily 1 group F member 1
, retinoic acid receptor-related orphan receptor alpha
, retinoid-related orphan receptor alpha
, thyroid hormone nuclear receptor alpha variant 4
, transcription factor RZR-alpha
, retinoid-related orphan receptor-alpha