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Cigarette smoking may contribute to this imbalance by affecting the polarization and survival of Th/Tregs through the up-regulation of MR3 and MR5.
Immunological stimulation leads to M5 mAChR (show CHRM3 Proteins) gene expression in lymphocytes.
direct evidence suggesting that the M5 muscarinic receptor gene combined with the alpha7-nicotinic receptor (show CHRNA7 Proteins) gene may be linked to schizophrenia
mAChR (show CHRM3 Proteins) subtypes (m1 to m5)presents in human scleral fibroblasts at both mRNA and protein levels.
the first study to show an association between CHRM5 and substance use in humans
acetylcholine, a potent dilator of most vascular beds, virtually lost the ability to dilate cerebral arteries and arterioles in M5 muscarinic receptor -/- mice, suggesting that endothelial M(5) receptors mediate this activity in wild-type mice--review
Male M5R-/- mice exhibited a significantly reduced cerebral blood flow (CBF) in the cerebral cortex, hippocampus, basal ganglia, and thalamus. Cortical and hippocampal pyramidal neurons from M5R-/- mice showed neuronal atrophy.
M2 and M5 muscarinic receptors but not M4 muscarinic receptor or D2 dopamine receptors are needed for male USV production during male-female interactions
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
muscarinic acetylcholine receptor M5
, cholinergic receptor, muscarinic 5
, muscarinic cholinergic receptor like
, G-protein coupled neurotransmitter receptor
, M5 muscarinic acetylcholine receptor
, acetylcholine receptor, muscarinic 5
, muscarinic acetylcholine receptor 5
, muscarinic receptor