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The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
both rs578776 and rs938682 of CHRNA3 were significantly associated with the susceptibility of lung cancer.
the association of 3 selected single-nucleotide polymorphisms (CHRNA3 rs1051730, rs6495308, and CHRNA5 rs55853898) with nicotine dependence in an isolated population of Kashubians from Poland, is reported.
CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
focus on the CHRNA5/A3/B4 gene cluster and its role in nicotine dependence (review)
At CHRNA3, allele G of rs3743078 was associated with increased nicotine craving.
Our data suggest that gene variance in the CHRNA5 (show CHRNA5 ELISA Kits)-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD (show ARCN1 ELISA Kits) and tobacco-related cancer in smokers.
two SNPs (rs6495308 and rs11072768) in CHRNA5-A3-B4 have a indirect effect on lung cancer through smoking behaviors
CHRNA3 - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.
Data suggest that CHRNA5-A3-B4 gene variants do not exhibit a robust association with smoking cessation and are unlikely to be useful for clinically optimizing smoking cessation pharmacotherapy for Caucasian smokers.
neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR (show CHRNA4 ELISA Kits)-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease
The alpha3beta4* nicotinic ACh (show FGFR3 ELISA Kits) receptor subtype mediates physical dependence to morphine
The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR (show CHRNA4 ELISA Kits) containing the alpha3-subunit.
Downregulation of nAChR (show CHRNA4 ELISA Kits) subunit and PSD-93 (show DLG2 ELISA Kits) expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (show MPG ELISA Kits) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.
findings suggest an important role for the a3b4* nAChR (show CHRNA4 ELISA Kits) subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome.
Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated.
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys (show DNAJC5 ELISA Kits) residues on the alpha3 subunit
functional nicotinic ACh (show FGFR3 ELISA Kits) receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10
Our results suggest that PrP(C (show PRNP ELISA Kits)) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR (show CHRNA4 ELISA Kits).
Data show that a basic residue at position 210 of alpha3 subunit decreases the assembly of heteromeric neuronal alpha3beta4 nicotinic ACh (show FGFR3 ELISA Kits) receptors.
Sympathetic alpha3beta2-nAChRs (CHRNA3/CHRNB2 (show CHRNB2 ELISA Kits)) mediate basilar artery neurogenic nitrergic vasodilation in swine.
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
cholinergic receptor, nicotinic, alpha polypeptide 3
, neuronal acetylcholine receptor subunit alpha-3
, neuronal nicotinic acetylcholine receptor, alpha3 subunit
, neuronal acetylcholine receptor subunit alpha-3-like
, cholinergic receptor, nicotinic, alpha 3
, alpha 3
, neuronal nicotinic acetylcholine receptor, alpha 3 subunit
, Acetylcholine receptor alpha 3 (neuronal nicotine)
, cetylcholine receptor alpha 3 (neuronal nicotine)
, cholinergic receptor nicotinic alpha polypeptide 4
, neuronal nicotinic acetylcholine receptor subunit 3