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Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.
the Drosophila silver gene corresponds to a Carboxypeptidase D-like protein with three carboxypeptidase-like domains, a transmembrane domain, and a cytosolic tail
The molecular basis for the phenotype of 3 carboxypeptidase D mutations are presented.
Data show that Drosophila S2 cells produce multiple forms of carboxypeptidase D with different intracellular distributions.
Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR (show MLXIP Antibodies)-214
The human carboxypeptidase D transthyretin (show TTR Antibodies)-like domain forms amyloid under physiological conditions.
Prolactin (show PRL Antibodies) and R1881, acting through Stat5 (show STAT5A Antibodies) and androgen receptor (show AR Antibodies), act cooperatively to stimulate CPD gene transcription in breast cancer cells.
CPD immunostaining and testosterone/prolactin (show PRL Antibodies)-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin (show PRL Antibodies) receptors were inhibited.
Carboxypeptidase D (CPD) is frequently upregulated in hepatocellular carcinoma; targeting CPD inhibits hepatocellular carcinoma cell proliferation through induction of G1 cell-cycle arrest and apoptosis.
Either high glucose or insulin (show INS Antibodies) (with low glucose) up-regulates beta-cell CPD (but not CPE (show CPE Antibodies)).
Palmitoylation of carboxypeptidase D has a role in intracellular trafficking
The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
First report to demonstrate carboxypeptidase D as part of the transforming growth factor (TGF)-beta (show TGFB1 Antibodies) pathway as a TGF-beta (show TGFB1 Antibodies) target gene implicated in the pathogenesis of lupus erythematosus.
prolactin (show PRL Antibodies) or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival
stress-alcohol locomotor cross-sensitization was regulated by Homer2 (show HOMER2 Antibodies).
NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 (show HOMER2 Antibodies) gene
mouse mutants homozygous for the targeted deletion of Homer2 (show HOMER2 Antibodies) present with early-onset rapidly progressive hearing loss.
Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (show ATP2B2 Antibodies) (PMCA) by Homer2 (show HOMER2 Antibodies) protein that has a central role on PMCA-mediated Ca(2 (show CA2 Antibodies)+) signaling in parotid acinar cells.
This study deministrated that PFC (show CFP Antibodies) Homer2 (show HOMER2 Antibodies) overexpression enhances cocaine-conditioned reward in mice.
Homer (show HOMER1 Antibodies) 1b/c isoform is identical irrespective of the muscle; Homer (show HOMER1 Antibodies) 2a/b is instead characteristic of the slow-twitch phenotype.
These data support the over-arching hypothesis that augmented accumbens Homer2 (show HOMER2 Antibodies)-mediated glutamate (show GRIN1 Antibodies) signaling may be an endophenotype related to genetic variance in alcohol consumption
Homer2 (show HOMER2 Antibodies) tunes G protein-coupled receptors stimulus intensity by regulating RGS (show PITX2 Antibodies) proteins and PLCbeta GAP activities.
In the developing olfactory bulb, Cupidin (show HOMER2 Antibodies)/Homer (show HOMER1 Antibodies) 2a/b is up-regulated in the granular, external plexiform, and glomerular layers
Homer2 (show HOMER2 Antibodies) KO mice demonstrate enhanced locomotor stimulant and conditioned place preference responses to cocaine
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
, carboxypeptidase D
, carboxypeptidase E
, metallocarboxypeptidase D
, VASP/Ena-related gene up-regulated during seizure and LTP 2
, homer protein homolog 2
, homer, neuronal immediate early gene, 2