Browse our CX3CL1 Proteins (CX3CL1)

Full name:
Chemokine (C-X3-C Motif) Ligand 1 Proteins (CX3CL1)
On www.antibodies-online.com are 73 Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) Proteins from 19 different suppliers available. Additionally we are shipping CX3CL1 Antibodies (269) and CX3CL1 Kits (86) and many more products for this protein. A total of 445 CX3CL1 products are currently listed.
Synonyms:
AB030188, ABCD-3, AI848747, C3Xkine, CX3C, Cx3C-rs1, CX3CL1, CXC3, CXC3C, D8Bwg0439e, DKFZp459K117, fractalkine, neurotactin, NTN, NTT, SCYD1, Scyd1-rs1
list all proteins Gene Name GeneID UniProt
CX3CL1 110894  
CX3CL1 89808 O55145
CX3CL1 6376 P78423

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CX3CL1 Proteins (CX3CL1) by Origin

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Top referenced CX3CL1 Proteins

  1. Rat (Rattus) CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN2666797 : Hundhausen, Misztela, Berkhout, Broadway, Saftig, Reiss, Hartmann, Fahrenholz, Postina, Matthews, Kallen, Rose-John, Ludwig: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. in Blood 2003 (PubMed)
    Show all 8 references for 2666797

  2. Mouse (Murine) CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN2666624 : Hamann, Unterwalder, Cardona, Meisel, Zipp, Ransohoff, Infante-Duarte: Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells. in Immunology 2011 (PubMed)
    Show all 7 references for 2666624

  3. Human CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN2666622 : Hundhausen, Schulte, Schulz, Andrzejewski, Schwarz, von Hundelshausen, Winter, Paliga, Reiss, Saftig, Weber, Ludwig: Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 7 references for 2666622

  4. Human CX3CL1 Protein expressed in Human Cells - ABIN2003167 : Bazan, Bacon, Hardiman, Wang, Soo, Rossi, Greaves, Zlotnik, Schall: A new class of membrane-bound chemokine with a CX3C motif. in Nature 1997 (PubMed)
    Show all 3 references for 2003167

  5. Human CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN666659 : Papadopoulos, Sassetti, Saeki, Yamada, Kawamura, Fitzhugh, Saraf, Schall, Blauvelt, Rosen, Hwang: Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. in European journal of immunology 1999 (PubMed)
    Show all 2 references for 666659

  6. Cynomolgus CX3CL1 Protein expressed in Human Cells - ABIN2010151 : Imai, Hieshima, Haskell, Baba, Nagira, Nishimura, Kakizaki, Takagi, Nomiyama, Schall, Yoshie: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. in Cell 1997 (PubMed)
    Show all 2 references for 2010151

More Proteins for CX3CL1 Interaction Partners

Mouse (Murine) Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) interaction partners

  1. The CX3CL1/CX3CR1 (show CX3CR1 Proteins) system is essential for restricting coxsackievirus B3-induced myocarditis.

  2. changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine (show CCL1 Proteins) involved in the immune response that has been linked to AD and to other different neurological disorders.

  3. the individual and combined actions of CCL2 (show CCL2 Proteins)/CCR2 (show CCR2 Proteins) and CX3CL1/CX3CR1 (show CX3CR1 Proteins) in hypoxia-induced pulmonary hypertension in mice, is reported.

  4. Medial ganglionic eminence (MGE) interneurons secrete fractalkine that promotes genesis of oligodendrocytes from glially biased cortical precursors in culture. Moreover, when MGE interneurons are genetically ablated in vivo prior to their migration, this causes a deficit in cortical oligodendrogenesis.

  5. our findings reveal a previously unknown regulatory role for LRRK2 (show LRRK2 Proteins) in CX3CR1 (show CX3CR1 Proteins) signalling and suggest that an increase of CX3CR1 (show CX3CR1 Proteins) activity contributes to the attenuated inflammatory responses in Lrrk2 (show LRRK2 Proteins)-null microglia

  6. a crucial role of CX3CL1-CX3CR1 (show CX3CR1 Proteins) in experimental colitis, in particular for intestinal leukocyte recruitment during murine colitis, is reported.

  7. These results strongly suggest the involvement of CX3CL1 in the migration of osteoclast precursors and osteoclastogenesis.

  8. Authors provide evidence that interactions between CX3CL1 and CX3CR1 (show CX3CR1 Proteins) play crucial roles in determining the number of M1 macrophages within the skin of mice, which in turn can have dramatic effects on psoriasis-like inflammation.

  9. In the absence of the rd8 allele, deficiency of CCR2 (show CCR2 Proteins) and CX3CL1 in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (show CCL1 Proteins) signaling, but it does not recapitulate cardinal (show CARD8 Proteins) age-related macular degeneration features.

  10. Also icariin reduced CX3CR1 (show CX3CR1 Proteins) and CX3CL1 protein levels in the artery wall. In conclusion, icariin could be a potential anti-atherosclerosis agent by downregulating the expression of CX3CR1 (show CX3CR1 Proteins).

Human Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) interaction partners

  1. High CX3CL1 expression is associated with spinal metastases.

  2. High expression of CX3CR1 (show CX3CR1 Proteins) correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.

  3. changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine (show CCL1 Proteins) involved in the immune response that has been linked to AD and to other different neurological disorders.

  4. In conclusion, leukoplakia-associated fibroblasts produced and secreted less CX3CL1 by inhibiting the ERK (show EPHB2 Proteins) signaling pathway, thereby contributing to impaired cell resistance to Candida albicans.

  5. Fractalkine-CX3CR1 (show CX3CR1 Proteins) signaling has been shown to protect neurons.

  6. CX3CL1 exerts numerous effects on pathophysiological conditions that have both negative and positive consequences on pathogenesis and outcome [review]

  7. XCL2 (show XCL2 Proteins) and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The expression of XCL2 (show XCL2 Proteins) and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer.

  8. Recent works show that, in allergic diseases, there is an increased expression of fractalkine/CX3CL1 and its unique receptor CX3CR1 (show CX3CR1 Proteins) and that this chemokine (show CCL1 Proteins) does not act as chemoattractant. In allergic asthma, CX3CR1 (show CX3CR1 Proteins) expression regulates Th2 and Th1 (show TH1L Proteins) cell survival in the inflammatory lung, while, in atopic dermatitis, it regulate Th2 and Th1 (show TH1L Proteins) cell retention into the inflammatory site. [review]

  9. Post-transcriptional suppression of KSRP (show KHSRP Proteins) destabilizes CX3CL1 mRNA in liver epithelial cells.

  10. CX3CL1 increased the migration and invasiveness of DU145 and PC-3 (show PCSK1 Proteins), causing epithelial-to-mesenchymal transition. TACE (show ADAM17 Proteins)/TGF-alpha (show TGFA Proteins)/EGFR (show EGFR Proteins) pathway activation and Slug (show SNAI2 Proteins) upregulation were responsible for this.

CX3CL1 Protein Profile

Protein Summary

Chemotactic factor. Binds to CX3CR1.

Alternative names and synonyms associated with CX3CL1

  • chemokine (C-X3-C motif) ligand 1 (CX3CL1)
  • chemokine (C-X3-C motif) ligand 1, related sequence 1 (Cx3cl1-rs1)
  • chemokine (C-X3-C motif) ligand 1 (LOC100346186)
  • chemokine (C-X3-C motif) ligand 1 (Cx3cl1)
  • AB030188 protein
  • ABCD-3 protein
  • AI848747 protein
  • C3Xkine protein
  • CX3C protein
  • Cx3C-rs1 protein
  • CX3CL1 protein
  • CXC3 protein
  • CXC3C protein
  • D8Bwg0439e protein
  • DKFZp459K117 protein
  • fractalkine protein
  • neurotactin protein
  • NTN protein
  • NTT protein
  • SCYD1 protein
  • Scyd1-rs1 protein

Protein level used designations for CX3CL1

chemokine CX3CL1/FRACTALKINE , fractalkine , chemokine (C-X3-C motif) ligand 1 , chemokine (C-X3-C motif) ligand 1, related sequence 1 , small inducible cytokine subfamily D, 1-related sequence 1 , CX3CL1 chemokine , C-X3-C motif chemokine 1 , CX3C membrane-anchored chemokine , neurotactin , small inducible cytokine subfamily D, 1 , small-inducible cytokine D1 , small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) , small inducible cytokine subfamily D (Cys-X3-Cys), member-1

GENE ID SPECIES
574225 Macaca mulatta
454115 Pan troglodytes
100037930 Sus scrofa
100172425 Pongo abelii
110894 Mus musculus
415651 Gallus gallus
100346186 Oryctolagus cuniculus
100582586 Nomascus leucogenys
89808 Rattus norvegicus
20312 Mus musculus
6376 Homo sapiens
487265 Canis lupus familiaris
517354 Bos taurus
101119927 Ovis aries
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