Browse our anti-Gephyrin (GPHN) Antibodies

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anti-Gephyrin Antibodies (GPHN)
On are 84 Gephyrin (GPHN) Antibodies from 17 different suppliers available. Additionally we are shipping Gephyrin Proteins (4) and many more products for this protein. A total of 94 Gephyrin products are currently listed.
5730552E08Rik, AI662856, BC027112, C230040D23, DKFZp459M0825, Geph, gpgb1, GPH, GPHN, GPHRYN, HKPX1

Most Popular Reactivities for anti-Gephyrin (GPHN) Antibodies

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anti-Human Gephyrin Antibodies:

anti-Mouse (Murine) Gephyrin Antibodies:

anti-Rat (Rattus) Gephyrin Antibodies:

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Top referenced anti-Gephyrin Antibodies

  1. Chicken Monoclonal Gephyrin Primary Antibody for IF, IP - ABIN968050 : Feng, Tintrup, Kirsch, Nichol, Kuhse, Betz, Sanes: Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for 968050

  2. Human Polyclonal Gephyrin Primary Antibody for FACS, IHC (p) - ABIN952493 : Inada, Koga, Ishiguro, Horiuchi, Syu, Yoshio, Takahashi, Ozaki, Arinami: Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. in Pharmacogenetics and genomics 2008 (PubMed)
    Show all 2 references for 952493

  3. Chicken Monoclonal Gephyrin Primary Antibody for IF, IP - ABIN968898 : Meyer, Kirsch, Betz, Langosch: Identification of a gephyrin binding motif on the glycine receptor beta subunit. in Neuron 1995 (PubMed)
    Show all 2 references for 968898

More Antibodies against Gephyrin Interaction Partners

Zebrafish Gephyrin (GPHN) interaction partners

  1. duplicated gephyrin genes mediate Moco biosynthesis and control postsynaptic clustering of glycine receptor (show GLRB Antibodies)

Human Gephyrin (GPHN) interaction partners

  1. these data reveal that IQSEC3 (show IQSEC3 Antibodies) acts together with gephyrin to regulate inhibitory synapse development.

  2. A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified.

  3. A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.

  4. The N-terminal region of GABRA3 (show GABRA3 Antibodies) and the GlyR beta subunit (show POLG Antibodies) occupies the same binding site of gephyrin.

  5. Results show that PKC (show PRRT2 Antibodies)-dependent phosphorylation of GAP43 (show GAP43 Antibodies) plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.

  6. Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission.

  7. The enhancement of Cb-induced gephyrin clustering by GTP (show AK3 Antibodies)-TC10 (show RHOQ Antibodies) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors

  8. abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD.

  9. Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.

  10. Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism

Mouse (Murine) Gephyrin (GPHN) interaction partners

  1. Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA (show GABRg1 Antibodies) receptors, reduces LTP (show SCP2 Antibodies) and network excitability in the dentate gyrus.

  2. adult mice lacking interleukin-1 receptor 1 (show IL1RL1 Antibodies) (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95 (show DLGAP2 Antibodies)) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  3. The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/

  4. Data suggest that KIF5 (show KIF5A Antibodies) regulates gephyrin sorting by a mechanism that involves GSK3 (show GSK3b Antibodies) activity.

  5. Pin1 (show PIN1 Antibodies)-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (show MMEL1 Antibodies)/gephyrin interaction.

  6. These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII (show CAMK2G Antibodies)-dependent phosphorylation site on gephyrin.

  7. study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses

  8. Within this network, collybistin (show Arhgef9 Antibodies) can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.

  9. these findings suggest that gephyrin may be a key factor in BDNF (show BDNF Antibodies)-dependent GABAAR (show GABRG2 Antibodies) regulation in the amygdala.

  10. Data suggest that the loss of neurotransmitter receptor (show GRIN1 Antibodies) clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice.

Gephyrin (GPHN) Antigen Profile

Antigen Summary

This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described\; however, the full-length nature of all transcript variants is not currently known.

Alternative names and synonyms associated with Gephyrin (GPHN)

  • gephyrin (GPHN) antibody
  • gephyrin a (gphna) antibody
  • gephyrin (PTRG_08978) antibody
  • gephyrin (VDBG_00775) antibody
  • gephyrin (Tsp_03043) antibody
  • gephyrin (gphn) antibody
  • gephyrin (Gphn) antibody
  • 5730552E08Rik antibody
  • AI662856 antibody
  • BC027112 antibody
  • C230040D23 antibody
  • DKFZp459M0825 antibody
  • Geph antibody
  • gpgb1 antibody
  • GPH antibody
  • GPHN antibody
  • GPHRYN antibody
  • HKPX1 antibody

Protein level used designations for anti-Gephyrin (GPHN) Antibodies

gephyrin , gephyrin1 , gephyrin-like , gephyrin isoform , putative glycine receptor-tubulin linker protein

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490739 Canis lupus familiaris
535194 Bos taurus
268566 Mus musculus
64845 Rattus norvegicus
100153443 Sus scrofa
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