Browse our anti-GLRA1 (GLRA1) Antibodies

Full name:
anti-Glycine Receptor, alpha 1 Antibodies (GLRA1)
On are 54 Glycine Receptor, alpha 1 (GLRA1) Antibodies from 16 different suppliers available. Additionally we are shipping GLRA1 Proteins (6) and many more products for this protein. A total of 63 GLRA1 products are currently listed.
B230397M16Rik, GLYRA1, HKPX1, nmf11, oscillator, ot, spasmodic, spd, STHE, [a]Z1
list all antibodies Gene Name GeneID UniProt
GLRA1 25674 P07727
GLRA1 2741 P23415
GLRA1 14654  

Show all species

Show all synonyms

Most Popular Reactivities for anti-GLRA1 (GLRA1) Antibodies

Select your species and application

anti-Rat (Rattus) GLRA1 Antibodies:

anti-Human GLRA1 Antibodies:

anti-Mouse (Murine) GLRA1 Antibodies:

All available anti-GLRA1 Antibodies

Go to our pre-filtered search.

Top referenced anti-GLRA1 Antibodies

  1. Cow (Bovine) Polyclonal GLRA1 Primary Antibody for WB - ABIN2792243 : Schofield, Trudell, Harrison: Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. in Biochemistry 2004 (PubMed)

  2. Mouse (Murine) Polyclonal GLRA1 Primary Antibody for ELISA, WB - ABIN4314751 : Wang, Lynch: Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor. in The Journal of biological chemistry 2011 (PubMed)

More Antibodies against GLRA1 Interaction Partners

Human Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. The E103K startle mutation reduces the sensitivity of glycine receptor alpha 1 to both glycine and sarcosine and impairs channel gating.

  2. gain-of-function GLRA1 mutations also cause hyperekplexia, although the mechanism is unknown. Here we identify two new gain-of-function mutations (I43F and W170S) and characterize these along with known gain-of-function mutations (Q226E, V280M, and R414H) to identify how they cause hyperekplexia.

  3. GLRA1 and GLRB (show GLRB Antibodies) mutations are responsible for abnormal startled reactions in humans. (Review)

  4. in two sisters with hyperekplexia a compound heterozygosis of 2 novel mutations of GLRA1 gene was found - heterozygous for a C-to-G base transition resulting in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to arginine amino acid change in position 237

  5. the TM3 (show TPM1 Antibodies)-4 loop length is critical for glycine receptor (show GLRB Antibodies) alpha1 desensitization and a direct neighborhood of both basic stretches changes receptor properties from non-desensitizing to desensitizing.

  6. Mutations in the GLRA1 were identified in 16 Japanese patients with hyperekplexia.

  7. The first X-ray structure of the TMD (show TTN Antibodies) of the alpha1GlyR solved here using GLIC as a scaffold paves the way for mechanistic investigation and design of allosteric modulators of a human receptor.

  8. In GlyRA1 mutants, a portion of them can be transported to the plasma membrane but don't form funtional channels; a possible cause for hyperekplexia.

  9. Conformation and function of the human GLRA1 chloride channel (show CLCA1 Antibodies).

  10. Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor (show GLRB Antibodies) activation.

Zebrafish Glycine Receptor, alpha 1 (GLRA1) interaction partners

Mouse (Murine) Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. Glra1 receptor Beta8-Beta9 loop is an essential regulator of conformational rearrangements in ion channel opening and closing.

  2. Mutation of a zinc-binding residue in the glycine receptor (show GLRB Antibodies) alpha1 changes ethanol sensitivity in vitro and alcohol consumption in Glra1(D80A) knock-in mice.

  3. TM3 (show TPM1 Antibodies)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

  4. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, resulted in a small but general impairment of glycine action, that is most evident in the glycine-induced maximal currents.

  5. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, decreased specific behavioral actions of ethanol and altered other nonethanol behaviors, demonstrating the importance of GlyR function in diverse neuronal systems.

  6. The values of breathing frequency, tidal volume, and minute ventilation in newborn Glra1-deficient oscillator mice decrease rapidly during postnatal development.

  7. The new Glra1 mutation appears to affect glycine's inhibitory neurotransmission in the central nervous system (CNS) of the nmf11 homozygotes, which suffer from a severe startle disease-related phenotype and die by postnatal day 21.

  8. Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs (show GARS Antibodies), indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.

  9. These results show that insulin (show INS Antibodies) has a novel regulatory action on the potency of glycine for ionotropic glycine receptors.

GLRA1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GLRA1

  • glycine receptor, alpha 1 (GLRA1) antibody
  • glycine receptor subunit alpha-1-like (LOC100513384) antibody
  • glycine receptor, alpha 1 (Glra1) antibody
  • glycine receptor, alpha 1 (glra1) antibody
  • glycine receptor, alpha 1 subunit (Glra1) antibody
  • B230397M16Rik antibody
  • GLYRA1 antibody
  • HKPX1 antibody
  • nmf11 antibody
  • oscillator antibody
  • ot antibody
  • spasmodic antibody
  • spd antibody
  • STHE antibody
  • [a]Z1 antibody

Protein level used designations for GLRA1

glycine receptor, alpha 1 (startle disease/hyperekplexia) , glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) , glycine receptor, alpha 1 , glycine receptor subunit alpha-1-like , glycine receptor 48 kDa subunit , glycine receptor strychnine-binding subunit , glycine receptor subunit alpha-1 , glycine receptor, alpha 1 subunit , GlyR [a]Z1 , glycine receptor subunit alphaZ1 , glycine receptor, alphaZ1 subunit , glycine receptor alpha 1 subunit

471712 Pan troglodytes
100446940 Pongo abelii
100473634 Ailuropoda melanoleuca
100546420 Meleagris gallopavo
100513384 Sus scrofa
25674 Rattus norvegicus
2741 Homo sapiens
30676 Danio rerio
489172 Canis lupus familiaris
281783 Bos taurus
427637 Gallus gallus
100060055 Equus caballus
100344552 Oryctolagus cuniculus
14654 Mus musculus
Selected quality suppliers for anti-GLRA1 (GLRA1) Antibodies
Did you look for something else?