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Browse our GLRA1 (GLRA1) ELISA Kits

Full name:
Glycine Receptor, alpha 1 ELISA Kits (GLRA1)
On www.antibodies-online.com are 0 Glycine Receptor, alpha 1 (GLRA1) ELISA Kits from different suppliers available. Additionally we are shipping GLRA1 Antibodies (52) and GLRA1 Proteins (6) and many more products for this protein. A total of 61 GLRA1 products are currently listed.
Synonyms:
B230397M16Rik, GLYRA1, HKPX1, nmf11, oscillator, ot, spasmodic, spd, STHE, [a]Z1
list all ELISA KIts Gene Name GeneID UniProt
Rat GLRA1 GLRA1 25674 P07727
Human GLRA1 GLRA1 2741 P23415
Mouse GLRA1 GLRA1 14654  

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More ELISA Kits for GLRA1 Interaction Partners

Human Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. The E103K startle mutation reduces the sensitivity of glycine receptor alpha 1 to both glycine and sarcosine and impairs channel gating.

  2. gain-of-function GLRA1 mutations also cause hyperekplexia, although the mechanism is unknown. Here we identify two new gain-of-function mutations (I43F and W170S) and characterize these along with known gain-of-function mutations (Q226E, V280M, and R414H) to identify how they cause hyperekplexia.

  3. GLRA1 and GLRB (show GLRB ELISA Kits) mutations are responsible for abnormal startled reactions in humans. (Review)

  4. in two sisters with hyperekplexia a compound heterozygosis of 2 novel mutations of GLRA1 gene was found - heterozygous for a C-to-G base transition resulting in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to arginine amino acid change in position 237

  5. the TM3 (show TPM1 ELISA Kits)-4 loop length is critical for glycine receptor (show GLRB ELISA Kits) alpha1 desensitization and a direct neighborhood of both basic stretches changes receptor properties from non-desensitizing to desensitizing.

  6. Mutations in the GLRA1 were identified in 16 Japanese patients with hyperekplexia.

  7. The first X-ray structure of the TMD (show TTN ELISA Kits) of the alpha1GlyR solved here using GLIC as a scaffold paves the way for mechanistic investigation and design of allosteric modulators of a human receptor.

  8. In GlyRA1 mutants, a portion of them can be transported to the plasma membrane but don't form funtional channels; a possible cause for hyperekplexia.

  9. Conformation and function of the human GLRA1 chloride channel (show CLCA1 ELISA Kits).

  10. Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor (show GLRB ELISA Kits) activation.

Zebrafish Glycine Receptor, alpha 1 (GLRA1) interaction partners

Mouse (Murine) Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. Mutation of a zinc-binding residue in the glycine receptor (show GLRB ELISA Kits) alpha1 changes ethanol sensitivity in vitro and alcohol consumption in Glra1(D80A) knock-in mice.

  2. TM3 (show TPM1 ELISA Kits)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

  3. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, resulted in a small but general impairment of glycine action, that is most evident in the glycine-induced maximal currents.

  4. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, decreased specific behavioral actions of ethanol and altered other nonethanol behaviors, demonstrating the importance of GlyR function in diverse neuronal systems.

  5. The values of breathing frequency, tidal volume, and minute ventilation in newborn Glra1-deficient oscillator mice decrease rapidly during postnatal development.

  6. The new Glra1 mutation appears to affect glycine's inhibitory neurotransmission in the central nervous system (CNS) of the nmf11 homozygotes, which suffer from a severe startle disease-related phenotype and die by postnatal day 21.

  7. Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs (show GARS ELISA Kits), indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.

  8. These results show that insulin (show INS ELISA Kits) has a novel regulatory action on the potency of glycine for ionotropic glycine receptors.

GLRA1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GLRA1

  • glycine receptor, alpha 1 (GLRA1) Elisa Kit
  • glycine receptor subunit alpha-1-like (LOC100513384) Elisa Kit
  • glycine receptor, alpha 1 (Glra1) Elisa Kit
  • glycine receptor, alpha 1 (glra1) Elisa Kit
  • glycine receptor, alpha 1 subunit (Glra1) Elisa Kit
  • B230397M16Rik Elisa Kit
  • GLYRA1 Elisa Kit
  • HKPX1 Elisa Kit
  • nmf11 Elisa Kit
  • oscillator Elisa Kit
  • ot Elisa Kit
  • spasmodic Elisa Kit
  • spd Elisa Kit
  • STHE Elisa Kit
  • [a]Z1 Elisa Kit

Protein level used designations for GLRA1

glycine receptor, alpha 1 (startle disease/hyperekplexia) , glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) , glycine receptor, alpha 1 , glycine receptor subunit alpha-1-like , glycine receptor 48 kDa subunit , glycine receptor strychnine-binding subunit , glycine receptor subunit alpha-1 , glycine receptor, alpha 1 subunit , GlyR [a]Z1 , glycine receptor subunit alphaZ1 , glycine receptor, alphaZ1 subunit , glycine receptor alpha 1 subunit

GENE ID SPECIES
471712 Pan troglodytes
100446940 Pongo abelii
100473634 Ailuropoda melanoleuca
100546420 Meleagris gallopavo
100513384 Sus scrofa
25674 Rattus norvegicus
2741 Homo sapiens
30676 Danio rerio
489172 Canis lupus familiaris
281783 Bos taurus
427637 Gallus gallus
100060055 Equus caballus
100344552 Oryctolagus cuniculus
14654 Mus musculus
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