Browse our anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Antibodies

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anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Antibodies (KCNB1)
On www.antibodies-online.com are 80 Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Antibodies from 17 different suppliers available. Additionally we are shipping Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Proteins (6) and many more products for this protein. A total of 91 Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 products are currently listed.
Synonyms:
DRK1, DRK1PC, h-DRK1, Kcnb1, Kcr1-1, KV2.1, Shab
list all antibodies Gene Name GeneID UniProt
KCNB1 16500 Q03717
KCNB1 25736 P15387
KCNB1 3745 Q14721

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Most Popular Reactivities for anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Antibodies

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All available anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Antibodies

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Top referenced anti-Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Antibodies

  1. Human Polyclonal KCNB1 Primary Antibody for ELISA, WB - ABIN1450716 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)

  2. Cow (Bovine) Polyclonal KCNB1 Primary Antibody for WB - ABIN2778213 : Adair, Nunn, Lewis, Dukes, Philipson, Yeager: Single particle image reconstruction of the human recombinant Kv2.1 channel. in Biophysical journal 2008 (PubMed)

  3. Human Polyclonal KCNB1 Primary Antibody for ELISA, WB - ABIN238567 : Park, Mohapatra, Misonou, Trimmer: Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. in Science (New York, N.Y.) 2006 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Spinal Musculature Atrophy motor neurons showed a lower surface expression of Kv2.1 potassium channels and reduced spiking ability.

  2. This study provides the first experimental evidence that oxidation of a K(+) channel (show KCNC4 Antibodies) constitutes a mechanism of neuronal and cognitive impairment in vertebrates. Specifically, the interaction of KCNB1 channels with reactive oxygen species plays a major role in the etiology of mouse model of traumatic brain injury (TBI), a condition associated with extensive oxidative stress. In addition, a Food and Drug Administration-app (show APP Antibodies)

  3. The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.

  4. major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 channel and intracellular RyR (show RYR1 Antibodies) Ca2 (show CA2 Antibodies)+ release channels

  5. study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150 (show AKAP5 Antibodies)-CaN/NFATc3 (show NFATC3 Antibodies) signaling axis contributes to enhanced arterial tone during diabetes

  6. These results showed that a modest suppression of Kv2.1 channels dramatically raises insulinotropic potency of GLP-1 (show GCG Antibodies)-based drugs.

  7. Kv2.1 knockout mice are strikingly hyperactive, defective in spatial learning and hypersensitive to convulsants.

  8. the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src (show SRC Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway.

  9. Kv2.1 regulates insulin (show INS Antibodies) secretion in beta-cells

  10. Direct interaction between syntaxin 1A (show STX1A Antibodies) and the Kv2.1 C-terminus is required for efficient insulin (show INS Antibodies) exocytosis and glucose-stimulated insulin (show INS Antibodies) secretion.

Human Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Kv2.1, but not Kv2.2 (KCNB2 (show KCNB2 Antibodies)), forms clusters of 6-12 tetrameric channels at the plasma membrane and facilitates insulin (show INS Antibodies) exocytosis. Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane. KCNB1 appears reduced in T2D islets, and further knockdown of KCNB1 does not inhibit Kv current in T2D beta-cells. Upregulation of Kv2.1-wild-type, but not Kv2.1-DeltaC318, rescues the exocytotic phen...

  2. the first six N-terminal residues including Lys (show LYZ Antibodies)-3, Lys (show LYZ Antibodies)-4, and Leu-5 (show TRIM13 Antibodies) are critical for controlling functional regulation, but not trafficking, of BK channels. This membrane-distal region has features of an amphipathic helix that is predicted to control the orientation of the first transmembrane-spanning domain (TM1 (show TPM2 Antibodies)) of the beta1-subunit.

  3. Perifosine modified the Kv2.1 inactivation gating resulting in a decrease of the current amplitude.

  4. KCNB1 is a strong susceptibility gene for schizophrenia spectrum disorders in humans.

  5. inactivation regulation via Ca(2 (show CA2 Antibodies)+)/calmodulin (show CALM1 Antibodies) does not interfere with the beta subunit's enzymatic activity as an NADPH (show NQO1 Antibodies)-dependent oxidoreductase (show TXNRD1 Antibodies), thus rendering the Kvb1.1 subunit a multifunctional receptor

  6. Kv2.1 functional aberrations in humans are associated with developmental delay, infantile generalized seizures, hypotonia, and behavioural problems, and also highlight a critical role for Kv2.1 in regulating neuronal firing in neuronal circuits.

  7. Epileptic V378A variant in KCNB1 changes ion selectivity, trafficking and expression of Kv2.1 channel.

  8. KCNE5 subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 (show Kcng4 Antibodies) heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.

  9. KvS subunits modify the pharmacological response of Kv2 (show KCNA6 Antibodies) subunits when assembled in heterotetramers and illustrate the potential of KvS subunits to provide unique properties to the heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 (show Kcng4 Antibodies) channels.

  10. The results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome.

Rabbit Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Analysis of the data suggested that Kv2.1 channels contribute significantly to the voltage-gated potassium current in smooth muscle cells from rabbit urethra.

Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Antigen Profile

Antigen Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

Alternative names and synonyms associated with Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1)

  • potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1) antibody
  • potassium voltage-gated channel, Shab-related subfamily, member 1 (kcnb1) antibody
  • delayed rectifier potassium channel Kv2.1 (DRK1) antibody
  • potassium voltage gated channel, Shab-related subfamily, member 1 (Kcnb1) antibody
  • DRK1 antibody
  • DRK1PC antibody
  • h-DRK1 antibody
  • Kcnb1 antibody
  • Kcr1-1 antibody
  • KV2.1 antibody
  • Shab antibody

Protein level used designations for KCNB1

Voltage-gated potassium channel subunit Kv2.1 , potassium voltage-gated channel subfamily B member 1 , potassium voltage-gated channel, Shab-related subfamily, member 1 , voltage gated potassium channel subtype 2.1 , potassium voltage-gated channel subfamily B member 1-like , delayed rectifier potassium channel 1 , voltage-gated potassium channel subunit Kv2.1 , DRK1 , potassium channel Kv2.1 , delayed rectifier potassium channel Kv2.1 , h-DRK1 K(+) channel , potassium channel protein DRK1 , voltage-gated potassium channel Kv2.1

GENE ID SPECIES
703520 Macaca mulatta
780775 Ovis aries
100411630 Callithrix jacchus
100439566 Pongo abelii
100489405 Xenopus (Silurana) tropicalis
100541632 Meleagris gallopavo
428146 Gallus gallus
469965 Pan troglodytes
100023294 Monodelphis domestica
100591893 Nomascus leucogenys
397433 Sus scrofa
16500 Mus musculus
25736 Rattus norvegicus
3745 Homo sapiens
485918 Canis lupus familiaris
539528 Bos taurus
100008779 Oryctolagus cuniculus
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