Browse our Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) ELISA Kits

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Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 ELISA Kits (KCNB1)
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Synonyms:
DRK1, DRK1PC, h-DRK1, Kcnb1, Kcr1-1, KV2.1, Shab
list all ELISA KIts Gene Name GeneID UniProt
Mouse KCNB1 KCNB1 16500 Q03717
Rat KCNB1 KCNB1 25736 P15387
Human KCNB1 KCNB1 3745 Q14721

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More ELISA Kits for Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Spinal Musculature Atrophy motor neurons showed a lower surface expression of Kv2.1 potassium channels and reduced spiking ability.

  2. This study provides the first experimental evidence that oxidation of a K(+) channel (show KCNC4 ELISA Kits) constitutes a mechanism of neuronal and cognitive impairment in vertebrates. Specifically, the interaction of KCNB1 channels with reactive oxygen species plays a major role in the etiology of mouse model of traumatic brain injury (TBI), a condition associated with extensive oxidative stress. In addition, a Food and Drug Administration-app (show APP ELISA Kits)

  3. The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.

  4. major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 channel and intracellular RyR (show RYR1 ELISA Kits) Ca2 (show CA2 ELISA Kits)+ release channels

  5. study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150 (show AKAP5 ELISA Kits)-CaN/NFATc3 (show NFATC3 ELISA Kits) signaling axis contributes to enhanced arterial tone during diabetes

  6. These results showed that a modest suppression of Kv2.1 channels dramatically raises insulinotropic potency of GLP-1 (show GCG ELISA Kits)-based drugs.

  7. Kv2.1 knockout mice are strikingly hyperactive, defective in spatial learning and hypersensitive to convulsants.

  8. the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src (show SRC ELISA Kits)/JNK (show MAPK8 ELISA Kits) signaling pathway.

  9. Kv2.1 regulates insulin (show INS ELISA Kits) secretion in beta-cells

  10. Direct interaction between syntaxin 1A (show STX1A ELISA Kits) and the Kv2.1 C-terminus is required for efficient insulin (show INS ELISA Kits) exocytosis and glucose-stimulated insulin (show INS ELISA Kits) secretion.

Human Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Kv2.1, but not Kv2.2 (KCNB2 (show KCNB2 ELISA Kits)), forms clusters of 6-12 tetrameric channels at the plasma membrane and facilitates insulin (show INS ELISA Kits) exocytosis. Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane. KCNB1 appears reduced in T2D islets, and further knockdown of KCNB1 does not inhibit Kv current in T2D beta-cells. Upregulation of Kv2.1-wild-type, but not Kv2.1-DeltaC318, rescues the exocytotic phen...

  2. the first six N-terminal residues including Lys (show LYZ ELISA Kits)-3, Lys (show LYZ ELISA Kits)-4, and Leu-5 (show TRIM13 ELISA Kits) are critical for controlling functional regulation, but not trafficking, of BK channels. This membrane-distal region has features of an amphipathic helix that is predicted to control the orientation of the first transmembrane-spanning domain (TM1 (show TPM2 ELISA Kits)) of the beta1-subunit.

  3. Perifosine modified the Kv2.1 inactivation gating resulting in a decrease of the current amplitude.

  4. KCNB1 is a strong susceptibility gene for schizophrenia spectrum disorders in humans.

  5. inactivation regulation via Ca(2 (show CA2 ELISA Kits)+)/calmodulin (show CALM1 ELISA Kits) does not interfere with the beta subunit's enzymatic activity as an NADPH (show NQO1 ELISA Kits)-dependent oxidoreductase (show TXNRD1 ELISA Kits), thus rendering the Kvb1.1 subunit a multifunctional receptor

  6. Kv2.1 functional aberrations in humans are associated with developmental delay, infantile generalized seizures, hypotonia, and behavioural problems, and also highlight a critical role for Kv2.1 in regulating neuronal firing in neuronal circuits.

  7. Epileptic V378A variant in KCNB1 changes ion selectivity, trafficking and expression of Kv2.1 channel.

  8. KCNE5 subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 (show Kcng4 ELISA Kits) heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.

  9. KvS subunits modify the pharmacological response of Kv2 (show KCNA6 ELISA Kits) subunits when assembled in heterotetramers and illustrate the potential of KvS subunits to provide unique properties to the heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 (show Kcng4 ELISA Kits) channels.

  10. The results indicate that KCNB1 is likely associated with metabolic traits that may either predispose or protect from progression to metabolic syndrome.

Rabbit Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) interaction partners

  1. Analysis of the data suggested that Kv2.1 channels contribute significantly to the voltage-gated potassium current in smooth muscle cells from rabbit urethra.

Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1) Antigen Profile

Antigen Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

Alternative names and synonyms associated with Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 1 (KCNB1)

  • potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1) Elisa Kit
  • potassium voltage-gated channel, Shab-related subfamily, member 1 (kcnb1) Elisa Kit
  • delayed rectifier potassium channel Kv2.1 (DRK1) Elisa Kit
  • potassium voltage gated channel, Shab-related subfamily, member 1 (Kcnb1) Elisa Kit
  • DRK1 Elisa Kit
  • DRK1PC Elisa Kit
  • h-DRK1 Elisa Kit
  • Kcnb1 Elisa Kit
  • Kcr1-1 Elisa Kit
  • KV2.1 Elisa Kit
  • Shab Elisa Kit

Protein level used designations for KCNB1

Voltage-gated potassium channel subunit Kv2.1 , potassium voltage-gated channel subfamily B member 1 , potassium voltage-gated channel, Shab-related subfamily, member 1 , voltage gated potassium channel subtype 2.1 , potassium voltage-gated channel subfamily B member 1-like , delayed rectifier potassium channel 1 , voltage-gated potassium channel subunit Kv2.1 , DRK1 , potassium channel Kv2.1 , delayed rectifier potassium channel Kv2.1 , h-DRK1 K(+) channel , potassium channel protein DRK1 , voltage-gated potassium channel Kv2.1

GENE ID SPECIES
703520 Macaca mulatta
780775 Ovis aries
100411630 Callithrix jacchus
100439566 Pongo abelii
100489405 Xenopus (Silurana) tropicalis
100541632 Meleagris gallopavo
428146 Gallus gallus
469965 Pan troglodytes
100023294 Monodelphis domestica
100591893 Nomascus leucogenys
397433 Sus scrofa
16500 Mus musculus
25736 Rattus norvegicus
3745 Homo sapiens
485918 Canis lupus familiaris
539528 Bos taurus
100008779 Oryctolagus cuniculus
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