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Microdeletion encompassing LRFN2 gene segregates with working memory deficits and learning disabilities in three family members.
enrichment of SALM1 on the cell surface affects dendritic arborization, and intracellular motifs regulate its dendritic versus axonal localization.
The Lrfn2 protein, a transmembrane adhesion-type molecule, is able to subvert hematopoietic differentiation to increase erythropoiesis.
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery.
fibronectin type III, immunoglobulin and leucine rich repeat domains 2
, leucine-rich repeat and fibronectin type-III domain-containing protein 2
, synaptic adhesion-like molecule 1