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The important role of this gene in the synapse and mental illness endophenotypes observed in animal models suggests that LRRC7 may play a role in susceptibility to bipolar disorder.
Characterization of a central Ca2 (show CA2 ELISA Kits)+/calmodulin (show CALM1 ELISA Kits)-dependent protein kinase (show CDK7 ELISA Kits) IIalpha/beta binding domain in densin that selectively modulates glutamate (show GRIN1 ELISA Kits) receptor subunit phosphorylation.
We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: LRRC7, TMEM132D, SEMA3A (show SEMA3A ELISA Kits), ALK (show ALK ELISA Kits), and STIP1 (show STIP1 ELISA Kits).
Densin-180 co-localized with delta-catenin/NPRAP (show CTNND2 ELISA Kits) at synapses in delta-catenin/NPRAP (show CTNND2 ELISA Kits) and may be involved in organization of the synaptic cell-cell junction through interaction with the delta-catenin/NPRAP (show CTNND2 ELISA Kits)-N-cadherin (show CDH2 ELISA Kits) complex
A novel splice variant, LRRC7, of densin-180 is located on 1p31 and consists of 8 exons. Unlike wild type, not brain-specific (show CALY ELISA Kits).
expressed by glomerular podocytes and has a role in associating with the nephrin (show NPHS1 ELISA Kits) interacting protein complex at the slit diaphragm
Densin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes.
Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells.
Densin may associate with the cadherin-catenin and nephrin (show NPHS1 ELISA Kits) complex(es), and may be involved in the formation of the cell-cell contacts.
common variants in LRRC7, KIRREL (show NEPH1 ELISA Kits), NPHS2 and ACTN4 (show ACTN4 ELISA Kits) do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
We report that the protein densin-180 is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 (show CACNA1C ELISA Kits) L-type Ca(2 (show CA2 ELISA Kits)+) channels in neurons. This interaction promotes coupling of Cav1.2 (show CACNA1C ELISA Kits) channels to activity-dependent gene transcription.
Characterization of a central Ca2 (show CA2 ELISA Kits)+/calmodulin-dependent protein kinase (show CDK7 ELISA Kits) IIalpha/beta binding domain in densin that selectively modulates glutamate (show GRIN1 ELISA Kits) receptor subunit phosphorylation.
This study demonstrated that Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 (show GRM5 ELISA Kits) and DISC1 (show DISC1 ELISA Kits) in the postsynaptic density fraction.
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity).
leucine rich repeat containing 7
, leucine-rich repeat-containing protein 7-like
, densin 13T-16
, densin 13T-17
, densin 13T-23
, densin 13T-29
, densin 13T-41
, densin 13T-43
, densin 13T-57
, densin 13T-57C
, densin 13T-72
, densin 13T-89
, leucine-rich repeat-containing protein 7
, densin 180