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CTNNA1 (show CTNNA1 Proteins) and CTNNA2 (show CTNNA2 Proteins) contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 (show LRRTM1 Proteins) genes, respectively.
The crystal structure of a thermostabilized LRRTM2 protein was determined.
Data indicate that neural Cell Adhesion Molecules Lrrtm1 (show LRRTM1 Proteins) and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling.
This study demonistrated that LRRTM2 is essential for maintenance of long-term potentiation in mice hippocampus.
The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2 (show CA2 Proteins)+)/CaM (show Calm2 Proteins)-dependent signaling pathway.
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B.
leucine rich repeat transmembrane neuronal 2
, leucine-rich repeat neuronal 2 protein
, leucine-rich repeat transmembrane neuronal 2 protein
, leucine-rich repeat transmembrane neuronal protein 2