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The nuclear and non-nuclear NELF (show NELF ELISA Kits) variant transcripts and proteins were identified, explaining variable NELF (show NELF ELISA Kits) cellular localization.
a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II, reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency.
NELF (show NELF ELISA Kits) is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene.
our findings implicate NELF (show NELF ELISA Kits) as a nuclear protein (show RDBP ELISA Kits) involved in the developmental function of the reproductive axis.
12% of Kallman syndrome males have KAL1 (show KAL1 ELISA Kits) deletions, but intragenic deletions of the FGFR1 (show FGFR1 ELISA Kits), GNRH1 (show GNRH1 ELISA Kits), GNRHR (show GNRHR ELISA Kits), GPR54 (show KISS1R ELISA Kits) and NELF (show NELF ELISA Kits) genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.
nasal embryonic LHRH factor
, nasal embryonic luteinizing hormone-releasing hormone factor