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Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 (show CACNA1A ELISA Kits) variant containing the region encoded by exons 44 and 47.
The function of RIM1/2 at rod ribbons is to enhance Cav1.4 (show CACNA1F ELISA Kits) channel activity, possibly through direct or indirect modulation of the channel.
Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking
RIM1alpha can influence short-term plasticity at cerebellar parallel-fibre synapses.
betaARs couple to a cAMP/Epac (show RAPGEF3 ELISA Kits)/PLC (show HSPG2 ELISA Kits)/Munc13-1 (show UNC13A ELISA Kits)/Rab3a (show RAB3A ELISA Kits)/RIM1a-dependent pathway to enhance glutamate (show GRIN1 ELISA Kits) release at cerebrocortical nerve terminals.
RIM1alpha has a role in synaptic vesicle tethering.
Presynaptic plasticity and function of RIM1a play an important part in the neuron's adaptive response to aberrant electrical activity following pharmacologically induced status epielepticus.
The interaction between RIM1alpha and Munc13-1 (show UNC13A ELISA Kits) is required for presynaptic long-term plasticity
Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2 (show CA2 ELISA Kits))+ channel density and vesicle docking at the active zone.
RIM1alpha interacts with several active zone molecules, including Munc13-1 (show UNC13A ELISA Kits) and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal.
The study identified a region on chromosome 6 comprising the genes SMAP1 (show UNC45A ELISA Kits), B3GAT2 (show B3GAT2 ELISA Kits), and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism.
Here, we report that, like Rab3A (show RAB3A ELISA Kits), RIM (show RBBP8 ELISA Kits) and Munc13 (show UNC13B ELISA Kits) are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin (show INS ELISA Kits) secretion.
Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.
Rim1 is a component of the presynaptic active zone and modulator of exocytosis and binds 14-3-3 (show YWHAQ ELISA Kits) through its N terminus
Even though the absence of pathogenic mutations suggests that RIM1 is notinvolved in autosomal recessive retinitis pigmentosa.
A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested.
The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene.
regulating synaptic membrane exocytosis 1
, regulating synaptic membrane exocytosis protein 1-like
, regulating synaptic membrane exocytosis protein 1
, RIM 1
, Rab3 effector
, Rab3 interacting protein 1
, rab-3-interacting molecule 1
, rab-3-interacting protein 1
, rab3-interacting molecule 1
, rab3-interacting protein 1
, synaptic exocytosis regulator 1
, RAB3-interacting protein 2
, rab-3-interacting protein 2
, Rim1b protein