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It was concluded that epithelial 5-HT3 receptor (show HTR3A ELISA Kits) may function as a mediator of gut (show GUSB ELISA Kits) microbiota-driven change in intestinal secretion.
Results indicate that vestibular ganglion cells express functional 5-HT3 receptor (show HTR3A ELISA Kits) channels (with 5-HT3a (show HTR3A ELISA Kits) and 5-HT3b subunits) and might play a modulatory role in the peripheral vestibular nervous system
adaptive changes occur in the subunit composition of enteric 5-HT(3 (show HTR3A ELISA Kits)) receptors of 5-HT (show DDC ELISA Kits) transporter -/- mice that are reflected in 5-HT(3 (show HTR3A ELISA Kits)) receptor affinity and desensitization
The 5-HT3B subunit alters the functional properties of 5-HT3 (show HTR3A ELISA Kits) receptors native to neuroblastoma (show ARHGEF16 ELISA Kits) cells.(rat 5-Ht3B)
5-HT (show DDC ELISA Kits) mediates enhanced neurogenic contractions of the mouse bladder muscle by an action at 5-HT(3 (show HTR3A ELISA Kits)) receptors. The presence of the 5-HT(3 (show HTR3A ELISA Kits)) receptor was confirmed by the expression of both 5-HT (show DDC ELISA Kits)(3A) and 5-HT(3B) receptor subunits.
the important role of HTR3B polymorphisms in heroin dependence among the Chinese Han population
The HTR3B rs1176744 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype.
the -AAG (show MPG ELISA Kits) deletion variant of the 5-HT3B receptor gene may contribute to variability in response to antiemetic therapy for chemotherapy-induced nausea and vomiting
Analysis of our small Chinese sample revealed a significant association of HTR3A (show HTR3A ELISA Kits) with bipolar disorder, but yielded no evidence of an association between HTR3B and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A (show HTR3A ELISA Kits).
Study demonstrates that the 5-HT3Br1 transcriptional variant of the 5-HT3B subunit can contribute to the functional properties of heteromeric receptors in a similar manner to the originally characterized 5-HT3B subunit
The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
HTR3B gene variants may contribute to variability in severity of and response to antiemetic therapy for nausea and vomiting of pregnancy.
we found an association of the HTR3B with poor concentration in schizophrenia patients.These results suggest that the HTR3B may be involved in the attention problem of schizophrenia in Korean population.
Data suggest that HTR3A (show HTR3A ELISA Kits)/HTR3B subunits readily form functionally distinct heteromeric receptors; molecular models have been developed regarding affinities of competitive ligands, non-competitive antagonists, and allosteric modulators. [REVIEW]
This is the first study to show an association between 5-HTR3B and PCS scores, thus suggesting a role of the serotonin pathway in pain catastrophizing.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor.
5-hydroxytryptamine (serotonin) receptor 3B
, 5-hydroxytryptamine receptor 3B-like
, 5-HT3 receptor subunit B
, 5-hydroxytryptamine receptor 3B
, serotonin receptor 3B
, 5-hydroxytryptamine 3 receptor B subunit
, serotonin-gated ion channel subunit