Browse our anti-SHANK3 (SHANK3) Antibodies

Full name:
anti-SH3 and Multiple Ankyrin Repeat Domains 3 Antibodies (SHANK3)
On www.antibodies-online.com are 103 SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) Antibodies from 15 different suppliers available. Additionally we are shipping SHANK3 Kits (1) and and many more products for this protein. A total of 108 SHANK3 products are currently listed.
Synonyms:
AI841104, DEL22q13.3, Prosap2, PSAP2, SCZD15, Shank3b, SPANK-2
list all antibodies Gene Name GeneID UniProt
SHANK3 85358 Q9BYB0
SHANK3 59312 Q9JLU4
SHANK3 58234 Q4ACU6

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anti-Human SHANK3 Antibodies:

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Top referenced anti-SHANK3 Antibodies

  1. Rat (Rattus) Polyclonal SHANK3 Primary Antibody for ICC, IHC - ABIN1742347 : Tao-Cheng, Toy, Winters, Reese, Dosemeci: Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses. in PLoS ONE 2016 (PubMed)
    Show all 4 references for 1742347

  2. Human Monoclonal SHANK3 Primary Antibody for AA, ICC - ABIN863129 : Durand, Betancur, Boeckers, Bockmann, Chaste, Fauchereau, Nygren, Rastam, Gillberg, Anckarsäter, Sponheim, Goubran-Botros, Delorme, Chabane, Mouren-Simeoni, de Mas, Bieth, Rogé, Héron, Burglen, Gillberg, Leboyer, Bourgeron: Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. in Nature genetics 2006 (PubMed)

  3. Rat (Rattus) Monoclonal SHANK3 Primary Antibody for ICC, IF - ABIN4353297 : Mayanagi, Yasuda, Sobue: PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)

More Antibodies against SHANK3 Interaction Partners

Zebrafish SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

Human SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. Partial knockdown of SHANK3 expression in human dorsal root ganglion neurons abrogates TRPV1 function.

  2. GWA study identified maternal genetic effects not previously identified in ASD (show ARSD Antibodies) at a locus in SHANK3.

  3. SHANK1 (show SHANK1 Antibodies) and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 (show RABGEF1 Antibodies) and R-Ras via the SPN (show SPN Antibodies) domain and thus limiting their bioavailability at the plasma membrane.

  4. No specific EEG abnormality is present in epilepsy due to to SHANK3 loss-of-function mutations.

  5. Haploinsufficiency of SHANK3 is a predisposing factor in adults with catatonia.

  6. post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7 (show LILRB1 Antibodies), miR (show MLXIP Antibodies)-34a, and miR (show MLXIP Antibodies)-504, is reported.

  7. these data suggest that SHANK3 mutations predispose to autism, at least partially, by inducing an Ih channelopathy that may be amenable to pharmacological intervention.

  8. De novo SHANK3 mutation causes Rett syndrome-like phenotype in a female patient.

  9. miR-7 (show LILRB1 Antibodies) binds to 3-prime untranslated regions of SHANK3 mRNA and causes the alteration of neuronal morphology and function, potentially playing a crucial role in the pathophysiological process of schizophrenia

  10. a mutation in SHANK3 that underscores its relevance in Autism Spectrum Disorder.

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) interaction partners

  1. Shank3 deletion preferentially affects synapses onto striatopallidal MSNs. Striatopallidal MSNs showed profound defects, including alterations in synaptic transmission, synaptic plasticity, and spine density.

  2. a mouse model of autism with deletions in Shank3 (Shank3B-/-) shows early cortical hyperactivity, which triggers increased SPN (show SPN Antibodies) excitatory synapse and corticostriatal hyperconnectivity.

  3. used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice

  4. Homozygous and heterozygous Shank3 complete knockout (Deltae4-22) results in impaired heat hyperalgesia in inflammatory and neuropathic pain. SHANK3 interacts with transient receptor potential subtype V1 (TRPV1 (show TRPV1 Antibodies)) via Proline-rich region and regulates TRPV1 (show TRPV1 Antibodies) surface expression.

  5. we characterized the behavioral, molecular and electrophysiological phenotypes of Shank3 mutant mice that were generated by deleting exon 11. The results of our molecular studies further indicate that Shank3 plays a major role in modulating mGlu5 (show GRM5 Antibodies) signaling by regulating Homer (show HOMER1 Antibodies) recruitment/localization to the PSD (show PSD Antibodies) in brain regions that are highly associated with ASD (show GUSB Antibodies)-like behavior.

  6. SHANK1 (show SHANK1 Antibodies) and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 (show TERF2IP Antibodies) and R-Ras via the SPN (show SPN Antibodies) domain and thus limiting their bioavailability at the plasma membrane.

  7. In the hippocampus, changes in synaptic Shank3 levels are influenced by circadian rhythm/melatonin concentration, while running activity increases and decreases levels of Shank3 in the cortex and striatum respectively

  8. Shank3 is a multi-domain, synaptic scaffolding protein that organizes proteins in the postsynaptic density of excitatory synapses.

  9. Cortical neurons cultured on MEAs displayed a rich repertoire of spontaneous firing, and Shank3 deletion led to reduced firing. MEA (show MEA1 Antibodies) recordings revealed electric phenotypes that displayed altered excitation and inhibition in the network lacking Shank3.

  10. "reduction of PV(+) neurons" was in all cases, i.e., in PV+/-, Shank1 (show SHANK1 Antibodies)-/- and Shank3B-/- mice, was due to a reduction in Pvalb (show PVALB Antibodies) mRNA and PV protein.

SHANK3 Antigen Profile

Antigen Summary

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

Alternative names and synonyms associated with SHANK3

  • SH3 and multiple ankyrin repeat domains 3 (SHANK3) antibody
  • SH3 and multiple ankyrin repeat domains protein 3 (shank3) antibody
  • SH3 and multiple ankyrin repeat domains 3 (Shank3) antibody
  • SH3/ankyrin domain gene 3 (Shank3) antibody
  • AI841104 antibody
  • DEL22q13.3 antibody
  • Prosap2 antibody
  • PSAP2 antibody
  • SCZD15 antibody
  • Shank3b antibody
  • SPANK-2 antibody

Protein level used designations for SHANK3

SH3 and multiple ankyrin repeat domains 3 , SH3 and multiple ankyrin repeat domains protein 3-like , SH3 and multiple ankyrin repeat domains protein 3 , proline rich synapse associated protein 2 , shank postsynaptic density protein , SH3/ankyrin domain gene 3 , SPANK-2 , Shank postsynaptic density protein 3a , proline-rich synapse-associated protein 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 1 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 2 , SH3 and multiple ankyrin repeat domains-like protein 3 variant 3 , SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1 , proSAP2

GENE ID SPECIES
100056993 Equus caballus
100447919 Pongo abelii
100482495 Ailuropoda melanoleuca
793484 Danio rerio
85358 Homo sapiens
59312 Rattus norvegicus
474456 Canis lupus familiaris
512428 Bos taurus
58234 Mus musculus
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