Browse our Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteins (SNTA1)

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Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteins (SNTA1)
On www.antibodies-online.com are 7 Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Proteins from 4 different suppliers available. Additionally we are shipping Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Antibodies (85) and Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Kits (3) and many more products for this protein. A total of 101 Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) products are currently listed.
Synonyms:
AW228934, dJ1187J4.5, LQT12, MGC147484, SNT1, SNTA1, TACIP1
list all proteins Gene Name GeneID UniProt
SNTA1 20648  
SNTA1 6640 Q13424
Rat SNTA1 SNTA1 362242  

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Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteins (SNTA1) by Origin

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Top referenced Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Proteins

  1. Human SNTA1 Protein expressed in Escherichia coli (E. coli) - ABIN668003 : Newey, Benson, Ponting, Davies, Blake: Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. in Current biology : CB 2001 (PubMed)
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More Proteins for Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) Interaction Partners

Xenopus laevis Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) interaction partners

  1. Ordered disorder of the astrocytic dystrophin (show DMD Proteins)-associated protein complex in the norm and pathology.

Mouse (Murine) Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) interaction partners

  1. alpha-syntrophin plays a pivotal role in the survival pathway triggered by menadione-induced oxidative stress in cultured myoblasts.

  2. Alpha-syntrophin deficiency markedly reduces astrocyte swelling during severe hypoosmotic stress/brain edema.

  3. Isolated muscle bundles from SNTA1 mutant mice showed reduced force production after hypo-osmotic shock. In addition, the mutant muscle bundles showed delayed recovery of specific gravity after being exposed to hypo-osmotic conditions.

  4. Ordered disorder of the astrocytic dystrophin (show DMD Proteins)-associated protein complex in the norm and pathology.

  5. alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS (show NOS1 Proteins) translocation and nNOS (show NOS1 Proteins)-dependent mitochondrial biogenesis.

  6. the removal of the perivascular pool of AQP4 (show AQP4 Proteins) due to alpha-syntrophin deletion reduces edema formation, especially under pathological conditions and during states associated with elevated K+.

  7. Scaffold proteins alpha-syntrophin and dystrophin (show DMD Proteins) exhibit lower densities in retinal microglia compared with brain astrocytes.

  8. The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A (show MAP1A Proteins), MAP1B (show MAP1B Proteins), and MAP1S (show MAP1S Proteins)) and alpha1-syntrophin is direct and occurs through the pleckstrin (show PLEK Proteins) homology domain 2 (PH2 (show PhC2 Proteins)).

  9. Data show that in Dp71 (show DMD Proteins)-null mice, the levels of beta-dystroglycan (beta-DG) and alpha1-syntrophin (alpha1-Syn (show SYP Proteins)) were lower and utrophin expression did not change, and the neuronal nitric oxide synthase (nNOS (show NOS1 Proteins)) expression and activity were increased.

  10. We identified alpha1-syntrophin, a component of the dystrophin (show DMD Proteins)-associated protein complex (DAPC), as a myocilin (show MYOC Proteins)-binding candidate.

Human Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) interaction partners

  1. A novel SNTA1 variant is likely causative for drug induced long-QT syndrome by augmenting the late sodium current.

  2. In a nonreferred nationwide Danish cohort of SIDS (show IDS Proteins) cases, up to 5/66 (7.5%) of SIDS (show IDS Proteins) cases can be explained by genetic variants in the sodium channel complex genes.

  3. our results present a possible mechanism of Rac1 activation involving SNTA1 and emphasise its role in ROS (show ROS1 Proteins) generation, cell migration, and acquisition of malignancy.

  4. Ordered disorder of the astrocytic dystrophin (show DMD Proteins)-associated protein complex in the norm and pathology.

  5. alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS (show NOS1 Proteins) translocation and nNOS (show NOS1 Proteins)-dependent mitochondrial biogenesis.

  6. Calcium homeostasis mishandling in Duchenne muscular dystrophy (show DMD Proteins) myotubes depends on store operated calcium entry under the influence alpha1-syntrophin regulation as well as TRPV2 (show TRPV2 Proteins)-dependant cation influx.

  7. The combined mutations of A261V-SNTA1 plus R800L-SCN5A (show SCN5A Proteins) increase the INa (show INA Proteins) current late/peak ratio and time constants of current decay.

  8. In contrast to stomach, lung, colon and rectal cancers, SNTA1 protein was found to be downregulated in esophageal cancers and upregulated in breast cancer.

  9. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction

  10. These results establish an SNTA1-based nNOS (show NOS1 Proteins) complex attached to SCN5A (show SCN5A Proteins) as a key regulator of sodium current and suggest that SNTA1 be considered a rare long QT syndrome-susceptibility gene.

Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) Protein Profile

Protein Summary

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Alternative names and synonyms associated with Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1)

  • syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (SNTA1)
  • syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (snta1)
  • syntrophin, acidic 1 (Snta1)
  • syntrophin, alpha 1 (SNTA1)
  • syntrophin, alpha 1 (Snta1)
  • AW228934 protein
  • dJ1187J4.5 protein
  • LQT12 protein
  • MGC147484 protein
  • SNT1 protein
  • SNTA1 protein
  • TACIP1 protein

Protein level used designations for SNTA1

syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) , 59 kDa dystrophin-associated protein A1 acidic component 1 , alpha-1-syntrophin , alpha1-syntrophin , syntrophin-1 , acidic alpha 1 syntrophin , dystrophin-associated protein A1, 59kDa, acidic component , pro-TGF-alpha cytoplasmic domain-interacting protein 1 , syntrophin, acidic 1 , 59-1 DAP , alpha-syntrophin

GENE ID SPECIES
458181 Pan troglodytes
496157 Xenopus laevis
709824 Macaca mulatta
780141 Xenopus (Silurana) tropicalis
100597246 Nomascus leucogenys
20648 Mus musculus
6640 Homo sapiens
362242 Rattus norvegicus
485837 Canis lupus familiaris
100151843 Sus scrofa
100009179 Oryctolagus cuniculus
527488 Bos taurus
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