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A retrograde signal mediated by Synaptotagmin 4 is transmitted to the postsynaptic cell through anterograde delivery of Synaptotagmin 4 via exosomes.
Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE (show NAPA ELISA Kits)-catalyzed membrane fusion.
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (show CA2 ELISA Kits)+) binding in the C(2)A domain
results demonstrate that acute plasticity and synapse-specific growth require Syt 4-dependent retrograde signaling at Drosophila neuromuscular junctions
Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 (show SYT1 ELISA Kits) as a Ca(2 (show CA2 ELISA Kits)+) sensor for presynaptic vesicle fusion.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3 (show BAG3 ELISA Kits), APOA1 (show APOA1 ELISA Kits), and VAV3 (show VAV3 ELISA Kits), except for VGF (show VGF ELISA Kits) protein, there was a trend between the expression of these four genes and their protein levels.
Synaptotagmin 4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased synaptotagmin 4 binding to vesicles.
BDNF (show BDNF ELISA Kits) secretion mediated by syt (show SS18 ELISA Kits)-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons
Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
these data suggest that syt (show SS18 ELISA Kits) IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals
propose that Syt (show SS18 ELISA Kits) IV is essential for the regulated release of glutamate (show GRIN1 ELISA Kits) from astrocytes and is a candidate Ca2 (show CA2 ELISA Kits)+ sensor for gliotransmission by these nonneuronal cells
Syt (show SS18 ELISA Kits) IV plays a role in rodent mood-related behavior by regulating synaptic function in the neuronal networks that modulate these behaviors.
Syt (show SS18 ELISA Kits) IV is a presynaptic negative regulator of short-term plasticity in area CA1 (show CA1 ELISA Kits) of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory.
Given the neuroendocrine functions of the posterior pituitary, changes in Syt (show SS18 ELISA Kits) IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin (show AVP ELISA Kits)
Thus, regulation of BDNF (show BDNF ELISA Kits) secretion by syt (show SS18 ELISA Kits)-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP (show SCP2 ELISA Kits).
From the results of this study the author proposed that the differential expression of synaptotagmins determines the characteristic Ca2 (show CA2 ELISA Kits)+ sensitivity of vesicle fusion at hair cell synapses.
The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues.
, synaptotagmin 4
, synaptotagmin IV