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Browse our anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies

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anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies (APBA1)
On www.antibodies-online.com are 78 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies from 21 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 86 Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 products are currently listed.
Synonyms:
6430513E09Rik, APBA1, D9S411E, Lin-10, LIN10, Mint, MINT1, Urop11, X11, X11A, X11ALPHA
list all antibodies Gene Name GeneID UniProt
APBA1 319924 B2RUJ5
APBA1 83589 O35430
APBA1 320 Q02410

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Most Popular Reactivities for anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antibodies

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anti-Mouse (Murine) Antibodies:

anti-Rat (Rattus) Antibodies:

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All available anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies

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Top referenced anti-Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Antibodies

  1. Human Polyclonal APBA1 Primary Antibody for EIA, IF - ABIN1450013 : Borg, Ooi, Levy, Margolis: The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. in Molecular and cellular biology 1996 (PubMed)
    Show all 4 references for ABIN1450013

  2. Mouse (Murine) Monoclonal APBA1 Primary Antibody for IF, IHC - ABIN968327 : Biederer, Südhof: Mints as adaptors. Direct binding to neurexins and recruitment of munc18. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN968327

  3. Human Polyclonal APBA1 Primary Antibody for EIA, WB - ABIN501114 : Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. in Journal of molecular endocrinology 2007 (PubMed)

  4. Human Polyclonal APBA1 Primary Antibody for ELISA, WB - ABIN451592 : Jacobs, Williams, Francis: Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. in Neuroscience 2006 (PubMed)

  5. Rat (Rattus) Polyclonal APBA1 Primary Antibody for ICC, IHC - ABIN1742315 : Boyken, Grønborg, Riedel, Urlaub, Jahn, Chua: Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. in Neuron 2013 (PubMed)

More Antibodies against Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Interaction Partners

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.

  2. Mint1 826 bridges APP (show APP Antibodies) to the small GTPase (show RACGAP1 Antibodies)

  3. Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (show UTS2R Antibodies) of Comt (catechol-O-methyltransferase (show COMT Antibodies)).

  4. Our data support a function for both GSK3 (show GSK3b Antibodies) and CDK5 (show CDK5 Antibodies) in amyloid precursor protein (show APP Antibodies) processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.

  5. Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin (show LEP Antibodies) action.

  6. Reports have demonstrated that KIF17 (show KIF17 Antibodies)-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser (show SIGLEC1 Antibodies) 1029 of KIF17 (show KIF17 Antibodies) was phosphorylated.

  7. X11s associate primarily with APP (show APP Antibodies) molecules that are outside of DRM (show GREM1 Antibodies), that the dissociation of APP (show APP Antibodies)-X11/X11L (show APBA2 Antibodies) complexes leads to entry of APP (show APP Antibodies) into DRM (show GREM1 Antibodies), and that cleavage of uncomplexed APP (show APP Antibodies) by BACE (show BACE Antibodies) within DRM (show GREM1 Antibodies)

  8. These results suggest that the three Mint/X11 proteins regulate Abeta (show APP Antibodies) production by a novel mechanism that may have implications for therapeutic approaches to altering APP (show APP Antibodies) cleavage in Alzheimer's disease.

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Mint1 causes amyloid precursor protein (show APP Antibodies) accumulation in the trans-Golgi network.

  2. Mints are necessary for activity-induced APP (show APP Antibodies) and PS1 (show PSEN1 Antibodies) trafficking and provide insight into the cellular fate of APP (show APP Antibodies) in endocytic pathways essential for Abeta (show APP Antibodies) production.

  3. Mint1 826 bridges APP (show APP Antibodies) to the small GTPase (show RACGAP1 Antibodies)

  4. an autoinhibitory mechanism in Mint1 is important for regulating APP (show APP Antibodies) processing and may provide novel therapies for Alzheimer's disease

  5. Transcriptional co-activators Taz (show TAZ Antibodies) and Yap (show YAP1 Antibodies) mediate signaling via the amyloid beta protein precursor paralogues APLP1 (show APLP1 Antibodies) and APLP2 (show APLP2 Antibodies) through interactions with Mint1 and Mint3 (show APBA3 Antibodies).

  6. Study identified the conserved binding site for the peptide on the CASK (show CASK Antibodies) calmodulin (show CALM1 Antibodies) kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.

  7. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.

  8. Methylation of MINT1 was significantly more prevalent in UC-CRC (show CALR Antibodies) cases compared with controls.

  9. ApoEr2 (show LRP8 Antibodies) regulates cell movement, and both X11alpha and Reelin (show RELN Antibodies) enhance this effect.

  10. A novel consensus sequence for interaction with the PDZ (show INADL Antibodies)-1 and PDZ (show INADL Antibodies)-2 domains of amyloid precursor protein (APP (show APP Antibodies))-interacting proteins Mint1, Mint2 (show APBA2 Antibodies), and Mint3 (show APBA3 Antibodies) is reported, with multiple novel interactors for these proteins.

Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

  • amyloid beta (A4) precursor protein-binding, family A, member 1 (APBA1) antibody
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1) antibody
  • ketopantoate reductase (apbA1) antibody
  • 2-dehydropantoate 2-reductase (apbA1) antibody
  • 2-dehydropantoate 2-reductase (apba1) antibody
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1) antibody
  • amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1) antibody
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1) antibody
  • 6430513E09Rik antibody
  • APBA1 antibody
  • D9S411E antibody
  • Lin-10 antibody
  • LIN10 antibody
  • Mint antibody
  • MINT1 antibody
  • Urop11 antibody
  • X11 antibody
  • X11A antibody
  • X11ALPHA antibody

Protein level used designations for APBA1

amyloid beta (A4) precursor protein-binding, family A, member 1 , amyloid beta A4 precursor protein-binding, family A, member 1 , amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , ketopantoate reductase , 2-dehydropantoate 2-reductase , Amyloid beta A4 precursor protein-binding family A member 1 , amyloid beta A4 precursor protein-binding family A member 1-like , UROP11-110 , adapter protein X11alpha , amyloid beta A4 precursor protein-binding family A member 1 , mint-1 , neuron-specific X11 protein , neuronal Munc18-1-interacting protein 1 , amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11) , amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , adaptor protein X11alpha , neuronal munc18-1-interacting protein 1 , phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

GENE ID SPECIES
472947 Pan troglodytes
565507 Danio rerio
699838 Macaca mulatta
4247161 Ralstonia eutropha H16
4606254 Azoarcus sp. BH72
9788884 Pantoea vagans C9-1
100380423 Salmo salar
100390315 Callithrix jacchus
100439123 Pongo abelii
100483732 Ailuropoda melanoleuca
100485825 Xenopus (Silurana) tropicalis
319924 Mus musculus
83589 Rattus norvegicus
320 Homo sapiens
427246 Gallus gallus
100686233 Canis lupus familiaris
100513711 Sus scrofa
515571 Bos taurus
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