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Mouse (Murine) Monoclonal APBA1 Primary Antibody for IF, IHC - ABIN968327
Biederer, Südhof: Mints as adaptors. Direct binding to neurexins and recruitment of munc18. in The Journal of biological chemistry 2001
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Mouse (Murine) Monoclonal APBA1 Primary Antibody for IF, IHC - ABIN968328
Wong, Setou, Teng, Takei, Hirokawa: Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 4 Pubmed References
Human Polyclonal APBA1 Primary Antibody for ELISA, WB - ABIN451592
Jacobs, Williams, Francis: Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. in Neuroscience 2006
Rat (Rattus) Polyclonal APBA1 Primary Antibody for ICC, IHC - ABIN1742315
Boyken, Grønborg, Riedel, Urlaub, Jahn, Chua: Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. in Neuron 2013
Human Polyclonal APBA1 Primary Antibody for ELISA, WB - ABIN1003416
Verlaeten, Casery, Cavagna, Naville, Giraudon, Belin, Begeot, Bernard: Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. in Journal of molecular endocrinology 2007
Results indicate that both X11 and X11L (show APBA2 Antibodies) exert largely in brain neurons, but X11 may also function in peripheral tissues.
Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.
Mint1 826 bridges APP (show APP Antibodies) to the small GTPase (show RACGAP1 Antibodies)
Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (show UTS2R Antibodies) of Comt (catechol-O-methyltransferase (show COMT Antibodies)).
Our data support a function for both GSK3 (show GSK3b Antibodies) and CDK5 (show CDK5 Antibodies) in amyloid precursor protein (show APP Antibodies) processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.
Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin (show LEP Antibodies) action.
Reports have demonstrated that KIF17 (show KIF17 Antibodies)-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser (show SIGLEC1 Antibodies) 1029 of KIF17 (show KIF17 Antibodies) was phosphorylated.
X11s associate primarily with APP (show APP Antibodies) molecules that are outside of DRM (show GREM1 Antibodies), that the dissociation of APP (show APP Antibodies)-X11/X11L (show APBA2 Antibodies) complexes leads to entry of APP (show APP Antibodies) into DRM (show GREM1 Antibodies), and that cleavage of uncomplexed APP (show APP Antibodies) by BACE (show BACE Antibodies) within DRM (show GREM1 Antibodies)
These results suggest that the three Mint/X11 proteins regulate Abeta (show APP Antibodies) production by a novel mechanism that may have implications for therapeutic approaches to altering APP (show APP Antibodies) cleavage in Alzheimer's disease.
Mint1 causes amyloid precursor protein (show APP Antibodies) accumulation in the trans-Golgi network.
Mints are necessary for activity-induced APP (show APP Antibodies) and PS1 (show PSEN1 Antibodies) trafficking and provide insight into the cellular fate of APP (show APP Antibodies) in endocytic pathways essential for Abeta (show APP Antibodies) production.
an autoinhibitory mechanism in Mint1 is important for regulating APP (show APP Antibodies) processing and may provide novel therapies for Alzheimer's disease
Transcriptional co-activators Taz (show TAZ Antibodies) and Yap (show YAP1 Antibodies) mediate signaling via the amyloid beta protein precursor paralogues APLP1 (show APLP1 Antibodies) and APLP2 (show APLP2 Antibodies) through interactions with Mint1 and Mint3 (show APBA3 Antibodies).
Study identified the conserved binding site for the peptide on the CASK (show CASK Antibodies) calmodulin kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.
Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Methylation of MINT1 was significantly more prevalent in UC-CRC (show CALR Antibodies) cases compared with controls.
ApoEr2 (show LRP8 Antibodies) regulates cell movement, and both X11alpha and Reelin (show RELN Antibodies) enhance this effect.
A novel consensus sequence for interaction with the PDZ (show INADL Antibodies)-1 and PDZ (show INADL Antibodies)-2 domains of amyloid precursor protein (APP (show APP Antibodies))-interacting proteins Mint1, Mint2 (show APBA2 Antibodies), and Mint3 (show APBA3 Antibodies) is reported, with multiple novel interactors for these proteins.
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
amyloid beta (A4) precursor protein-binding, family A, member 1
, amyloid beta A4 precursor protein-binding, family A, member 1
, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
, ketopantoate reductase
, 2-dehydropantoate 2-reductase
, Amyloid beta A4 precursor protein-binding family A member 1
, amyloid beta A4 precursor protein-binding family A member 1-like
, adapter protein X11alpha
, amyloid beta A4 precursor protein-binding family A member 1
, neuron-specific X11 protein
, neuronal Munc18-1-interacting protein 1
, amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11)
, amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
, adaptor protein X11alpha
, neuronal munc18-1-interacting protein 1
, phosphotyrosine-binding/-interacting domain (PTB)-bearing protein