Browse our Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) ELISA Kits

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Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 ELISA Kits (APBA1)
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Synonyms:
6430513E09Rik, APBA1, D9S411E, Lin-10, LIN10, Mint, MINT1, Urop11, X11, X11A, X11ALPHA
list all ELISA KIts Gene Name GeneID UniProt
Mouse APBA1 APBA1 319924 B2RUJ5
Rat APBA1 APBA1 83589 O35430
Human APBA1 APBA1 320 Q02410

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More ELISA Kits for Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 Interaction Partners

Mouse (Murine) Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Results indicate that both X11 and X11L (show APBA2 ELISA Kits) exert largely in brain neurons, but X11 may also function in peripheral tissues.

  2. Due to the multiple interacting partners of X11alpha, dysfunction or alteration in X11alpha will have a significant cellular effect.

  3. Mint1 826 bridges APP (show APP ELISA Kits) to the small GTPase (show RACGAP1 ELISA Kits)

  4. Expression of Apba1 in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (show UTS2R ELISA Kits) of Comt (catechol-O-methyltransferase (show COMT ELISA Kits)).

  5. Our data support a function for both GSK3 (show GSK3b ELISA Kits) and CDK5 (show CDK5 ELISA Kits) in amyloid precursor protein (show APP ELISA Kits) processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease.

  6. Can be considered a key molecule in the hypothalamic integration pathway, important as a target of leptin (show LEP ELISA Kits) action.

  7. Reports have demonstrated that KIF17-Mint1 association was disrupted and transported cargo was released from its microtubule-based transport when Ser 1029 of KIF17 was phosphorylated.

  8. X11s associate primarily with APP (show APP ELISA Kits) molecules that are outside of DRM (show GREM1 ELISA Kits), that the dissociation of APP (show APP ELISA Kits)-X11/X11L (show APBA2 ELISA Kits) complexes leads to entry of APP (show APP ELISA Kits) into DRM (show GREM1 ELISA Kits), and that cleavage of uncomplexed APP (show APP ELISA Kits) by BACE (show BACE ELISA Kits) within DRM (show GREM1 ELISA Kits)

  9. These results suggest that the three Mint/X11 proteins regulate Abeta (show APP ELISA Kits) production by a novel mechanism that may have implications for therapeutic approaches to altering APP (show APP ELISA Kits) cleavage in Alzheimer's disease.

Human Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) interaction partners

  1. Mint1 causes amyloid precursor protein (show APP ELISA Kits) accumulation in the trans-Golgi network.

  2. Mints are necessary for activity-induced APP (show APP ELISA Kits) and PS1 (show PSEN1 ELISA Kits) trafficking and provide insight into the cellular fate of APP (show APP ELISA Kits) in endocytic pathways essential for Abeta (show APP ELISA Kits) production.

  3. Mint1 826 bridges APP (show APP ELISA Kits) to the small GTPase (show RACGAP1 ELISA Kits)

  4. an autoinhibitory mechanism in Mint1 is important for regulating APP (show APP ELISA Kits) processing and may provide novel therapies for Alzheimer's disease

  5. Transcriptional co-activators Taz (show TAZ ELISA Kits) and Yap (show YAP1 ELISA Kits) mediate signaling via the amyloid beta protein precursor paralogues APLP1 (show APLP1 ELISA Kits) and APLP2 (show APLP2 ELISA Kits) through interactions with Mint1 and Mint3 (show APBA3 ELISA Kits).

  6. Study identified the conserved binding site for the peptide on the CASK (show CASK ELISA Kits) calmodulin (show CALM1 ELISA Kits) kinase domain. A related EPIWVMRQ peptide from Mint1 was also discovered to be sufficient for binding.

  7. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.

  8. Methylation of MINT1 was significantly more prevalent in UC-CRC (show CALR ELISA Kits) cases compared with controls.

  9. ApoEr2 (show LRP8 ELISA Kits) regulates cell movement, and both X11alpha and Reelin (show RELN ELISA Kits) enhance this effect.

  10. A novel consensus sequence for interaction with the PDZ (show INADL ELISA Kits)-1 and PDZ (show INADL ELISA Kits)-2 domains of amyloid precursor protein (APP (show APP ELISA Kits))-interacting proteins Mint1, Mint2 (show APBA2 ELISA Kits), and Mint3 (show APBA3 ELISA Kits) is reported, with multiple novel interactors for these proteins.

Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1)

  • amyloid beta (A4) precursor protein-binding, family A, member 1 (APBA1) Elisa Kit
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) (apba1) Elisa Kit
  • ketopantoate reductase (apbA1) Elisa Kit
  • 2-dehydropantoate 2-reductase (apbA1) Elisa Kit
  • 2-dehydropantoate 2-reductase (apba1) Elisa Kit
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (apba1) Elisa Kit
  • amyloid beta (A4) precursor protein binding, family A, member 1 (Apba1) Elisa Kit
  • amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1) Elisa Kit
  • 6430513E09Rik Elisa Kit
  • APBA1 Elisa Kit
  • D9S411E Elisa Kit
  • Lin-10 Elisa Kit
  • LIN10 Elisa Kit
  • Mint Elisa Kit
  • MINT1 Elisa Kit
  • Urop11 Elisa Kit
  • X11 Elisa Kit
  • X11A Elisa Kit
  • X11ALPHA Elisa Kit

Protein level used designations for APBA1

amyloid beta (A4) precursor protein-binding, family A, member 1 , amyloid beta A4 precursor protein-binding, family A, member 1 , amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , ketopantoate reductase , 2-dehydropantoate 2-reductase , Amyloid beta A4 precursor protein-binding family A member 1 , amyloid beta A4 precursor protein-binding family A member 1-like , UROP11-110 , adapter protein X11alpha , amyloid beta A4 precursor protein-binding family A member 1 , mint-1 , neuron-specific X11 protein , neuronal Munc18-1-interacting protein 1 , amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11) , amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) , adaptor protein X11alpha , neuronal munc18-1-interacting protein 1 , phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

GENE ID SPECIES
472947 Pan troglodytes
565507 Danio rerio
699838 Macaca mulatta
4247161 Ralstonia eutropha H16
4606254 Azoarcus sp. BH72
9788884 Pantoea vagans C9-1
100380423 Salmo salar
100390315 Callithrix jacchus
100439123 Pongo abelii
100483732 Ailuropoda melanoleuca
100485825 Xenopus (Silurana) tropicalis
319924 Mus musculus
83589 Rattus norvegicus
320 Homo sapiens
427246 Gallus gallus
100686233 Canis lupus familiaris
100513711 Sus scrofa
515571 Bos taurus
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