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we report for the first time a missense mutation of a novel lens specific gene STX3 in a phenotype associating autosomal recessive congenital cataract and intellectual disability.
GLUT5 (show SLC2A5 ELISA Kits) required an interaction cascade of Rab11 (show RAB11A ELISA Kits), Myo5B, Slp4a, Munc18-2 (show STXBP2 ELISA Kits), and Vamp7 (show VAMP7 ELISA Kits) with Stx3.
Rab11a (show RAB11A ELISA Kits)-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
the secretion of IL-1alpha, IL-1beta (show IL1B ELISA Kits), IL-12b (show IL12B ELISA Kits), and CCL4 (show CCL4 ELISA Kits) occurs during gelatinase degranulation, a process controlled by STX3.
The results showed that there was reduction in aggregation propensity of syntaxin-3 with point mutation at Val286.
hcmv-miR (show MLXIP ELISA Kits)-US33-5p-mediated inhibition of HCMV DNA synthesis and of viral replication are specifically mediated by down-regulation of STX3 expression.
loss of STX3 function causes variant microvillus inclusion disease
In insulin (show INS ELISA Kits) secretion, SYN-3 (show SYN3 ELISA Kits) plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS.
STX-3 and SNAP-23 (show SNAP23 ELISA Kits) are crucial for the release of all chemokines in mature human mast cells
These results demonstrate a function for STX3 in human cytomegalovirus morphogenesis, and unravel a new role for this SNARE (show NAPA ELISA Kits) protein in late endosomes/lysosomes compartments.
Phosphorylation of syntaxin 3B by CaMKII (show CAMK2G ELISA Kits) can modulate the assembly of the SNARE (show VTI1B ELISA Kits) complex in ribbon synapses of the retina.
The SNARE (show VTI1B ELISA Kits) machinery composed of VAMP7 (show VAMP7 ELISA Kits) on Tyrp1 (show TYRP1 ELISA Kits)-containing vesicles and syntaxin-3 and SNAP23 (show SNAP23 ELISA Kits) on melanosomes regulates Tyrp1 (show TYRP1 ELISA Kits) trafficking to the melanosome in melanocytes.
In insulin (show INS ELISA Kits) secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS.
Results show that cells in the mouse retina express only syntaxin 3B, while nonneuronal tissues, such as kidney, express only syntaxin 3A.
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants.
, syntaxin 3
, syntaxin 3A
, syntaxin 3B