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Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes.
Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4 (show SLC2A4 ELISA Kits).
Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
Syntaxin-8 regulates the endocytosis of TASK-1 (show KCNK3 ELISA Kits).
These results suggest that STX8 mediates the recycling of CLDN16 (show CLDN16 ELISA Kits) and constitutes an important component of the CLDN16 (show CLDN16 ELISA Kits) trafficking machinery in the kidney.
syntaxin 8 contributes to the regulation of CFTR (show CFTR ELISA Kits) trafficking and chloride channel (show CLCA1 ELISA Kits) activity by the SNARE (show NAPA ELISA Kits) machinery
Results report that syntaxin 7 (show STX7 ELISA Kits), syntaxin 8, vti1b (show VTI1B ELISA Kits) and VAMP8 (show VAMP8 ELISA Kits) physically and functionally interact with CFTR (show CFTR ELISA Kits).
Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes.
Syntaxin 8 and HECTd3 (show HECTD3 ELISA Kits) have similar subcellular localization.
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
, syntaxin 8
, t-SNARE family protein
, CIP-1-associated regulator of cyclin B
, syntaxin-like protein 3I35