anti-Human BCL10 antibody for Enzyme Immunoassay

Recommended BCL10 Antibody (supplied by: Log in to see )

Antigen
B-Cell CLL/lymphoma 10 (BCL10) Antibodies
  • CARMEN
  • CIPER
  • CLAP
  • c-E10
  • mE10
  • BCL10
  • AI132454
  • BCL-10
  • C81403
  • ME10
  • cE10
  • bcl10
  • B-cell CLL/lymphoma 10
  • B cell leukemia/lymphoma 10
  • B-cell lymphoma/leukemia 10
  • BCL10
  • Bcl10
  • bcl10
  • LOC100223183
Epitope
AA 27-55, N-Term
27
13
12
9
7
6
6
5
3
3
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
300
93
48
2
2
1
1
1
1
1
1
1
Host
Rabbit
175
122
4
Clonality
Polyclonal
Conjugate
This BCL10 antibody is un-conjugated
11
10
10
8
6
5
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
232
138
114
110
96
87
60
33
26
13
3
3
2
1
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Catalog No. ABIN950621
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1105500 EIA IF IHC (p) WB Mouse IgG1 Log in to see 4F8 3

General

Antigen B-Cell CLL/lymphoma 10 (BCL10) Antibodies
Epitope AA 27-55, N-Term
(27), (13), (12), (9), (7), (6), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(300), (93), (48), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(175), (122), (4)
Clonality
Polyclonal
Conjugate This BCL10 antibody is un-conjugated
(11), (10), (10), (8), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(232), (138), (114), (110), (96), (87), (60), (33), (26), (13), (3), (3), (2), (1)
Pubmed 5 references available
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Product Details anti-BCL10 Antibody

Target Details BCL10 Application Details Handling References for anti-BCL10 antibody (ABIN950621) Images
Specificity This antibody reats to Bcl-10.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human BCL10
Isotype Ig

Target Details BCL10

Product Details anti-BCL10 Antibody Application Details Handling References for anti-BCL10 antibody (ABIN950621) Images back to top
Antigen
Alternative Name Bcl-10 (BCL10 Antibody Abstract)
Background This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10
Gene ID 8915
NCBI Accession NP_003912
Research Area Cancer
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-BCL10 Antibody Target Details BCL10 Handling References for anti-BCL10 antibody (ABIN950621) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-BCL10 Antibody Target Details BCL10 Application Details References for anti-BCL10 antibody (ABIN950621) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-BCL10 antibody (ABIN950621)

Product Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling Images back to top
Background publications

Bhattacharyya, Borthakur, Dudeja, Tobacman: "Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations." in: Experimental cell research, Vol. 316, Issue 19, pp. 3317-27, 2010

Edin, Oruganti, Grundström, Grundström: "Interaction of calmodulin with Bcl10 modulates NF-kappaB activation." in: Molecular immunology, Vol. 47, Issue 11-12, pp. 2057-64, 2010

Rehman, Wang: "CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex." in: International journal of oral science, Vol. 1, Issue 3, pp. 105-18, 2010

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010

Bhattacharyya, Borthakur, Tyagi, Gill, Chen, Dudeja, Tobacman: "B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 522-30, 2009

Images

Product Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling References for anti-BCL10 antibody (ABIN950621) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 27-55), (N-Term) antibody (ABIN950621) BCL10 Antibody (N-term) flow cytometric analysis of MCF-7 cells (right histogram) com...
Immunofluorescence (IF) image for anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 27-55), (N-Term) antibody (ABIN950621) Confocal immunofluorescent analysis of BCL10 Antibody (N-term) (Cat#AP50354PU-N) with...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 27-55), (N-Term) antibody (ABIN950621) BCL10 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 10 (BCL10) (AA 27-55), (N-Term) antibody (ABIN950621) BCL10 Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35µg/la...