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single amino acid oncogenic CARD11 mutations can perturb or bypass the action of redundant inhibitory REs to achieve the level of hyperactive CARD11 signaling required to support lymphoma growth.
Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements.
CARMA1- and MyD88 (show MYD88 ELISA Kits)-dependent activation of Jun (show JUN ELISA Kits)/ATF-type AP-1 (show FOSB ELISA Kits) complexes is a hallmark of ABC (show ABCB6 ELISA Kits) diffuse large B-cell lymphomas.
Data show that caspase recruitment domain-containing protein 11/B-cell CLL/lymphoma 10 (show BCL10 ELISA Kits)/mucosa-associated lymphoid tissue lymphoma translocation gene 1 (show MALT1 ELISA Kits) signaling drives lymphoproliferation (show FAS ELISA Kits) through NF-kappa B (show NFKB1 ELISA Kits) and c-Jun N-terminal kinase activation.
CARD11-mediated alterations in NF-kappaB (show NFKB1 ELISA Kits) signaling may be an early event in the development of cutaneous squamous cell carcinoma
Taken together, our data indicate that miR (show MLXIP ELISA Kits)-539 is a novel regulator of migration and invasion in human thyroid cancer cells by targeting CARMA1.
CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB (show NFKB1 ELISA Kits) signalling
Both carried homozygous germline mutations in CARD11 (p.Cys150*), impairing NF-kappaB (show NFKB1 ELISA Kits) signaling and IL-2 (show IL2 ELISA Kits) production
Three patients have been described with mild B-cell lymphocytosis and a CARD11 C49Y missense mutation.
Overexpression of CARMA-BCL10 (show BCL10 ELISA Kits)-MALT in T-ALL may contribute to the constitutive cleavage and inactivation of A20 (show TNFAIP3 ELISA Kits), which enhances NF-kappaB (show NFKB1 ELISA Kits) signaling and may be related to T-ALL pathogenesis.
data suggest that Carma1 and MALT1 play previously unappreciated roles in the activation of mTOR signaling in T cells after engagement of the TCR.
CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism
Data indicate that caspase recruitment domain-containing protein 11 (CARD11) is involved in the pathogenesis of collagen-induced arthritis (CIA (show NCOA5 ELISA Kits)) by formation of the CARD11/Bcl10 (show BCL10 ELISA Kits) complex and enhancement of the Th17 cell response.
Genetic approach demonstrates a critical role for the CARD function of CARMA1 in Treg cell development in vivo.
both CARMA1 CARD and BCL10 CARD easily self-oligomerized under physiological conditions.
Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells.
TCR/CARMA1/NF-kappaB (show NFKB1 ELISA Kits) controls completion of Th17 differentiation.
These studies provide molecular insight into the assembly of CARMA1 and BCL10.
Upregulation of CARMA1 in vivo results in Th2 cell-mediated inflammation. Mice expressing constitutively active CARMA1 have elevated IL-4 (show IL4 ELISA Kits), IL-5 (show IL5 ELISA Kits), and IL-10 (show IL10 ELISA Kits) and spontaneously develop pulmonary inflammation and eosinophilia.
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
caspase recruitment domain family, member 11
, caspase recruitment domain-containing protein 11-like
, CARD-containing MAGUK protein 1
, bcl10-interacting maguk protein 3
, carma 1
, caspase recruitment domain-containing protein 11