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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||30 Antibodies||34 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies||4 Antibodies|
|Flow Cytometry (FACS)||3 Antibodies||3 Antibodies|
|Fluorescence Microscopy (FM)||1 Antibodies||1 Antibodies|
|Immunochromatography (IC)||2 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||3 Antibodies|
|Immunofluorescence (IF)||24 Antibodies||24 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||56 Antibodies|
|Immunohistochemistry (IHC)||34 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||21 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Western Blotting (WB)||72 Antibodies|
|Antigen||Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CBL antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
|3 references available|
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Product Details anti-CBL AntibodyTarget Details CBL Application Details Handling References for anti-CBL Antibody (ABIN968993) Images
|Immunogen||Purified recombinant fragment of human C-CBL expressed in E. coli.|
Target Details CBLProduct Details anti-CBL Antibody Application Details Handling References for anti-CBL Antibody (ABIN968993) Images back to top
|Alternative Name||C-CBL (CBL Antibody Abstract)|
|Background||The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.|
|Molecular Weight||120 kDa|
|Pathways||TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway|
Application DetailsProduct Details anti-CBL Antibody Target Details CBL Handling References for anti-CBL Antibody (ABIN968993) Images back to top
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CBL Antibody Target Details CBL Application Details References for anti-CBL Antibody (ABIN968993) Images back to top
|Buffer||Ascitic fluid containing 0.03 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 4 °C or at -20 °C for long term.|
References for anti-CBL Antibody (ABIN968993)Product Details anti-CBL Antibody Target Details CBL Application Details Handling Images back to top
|Product cited in:||
Sanada, Suzuki, Shih et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, 2009 (PubMed).
Loh, Sakai, Flotho et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, 2009 (PubMed).
Sproul, Xu, Wilhelm et al.: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, 2009 (PubMed).
ImagesProduct Details anti-CBL Antibody Target Details CBL Application Details Handling References for anti-CBL Antibody (ABIN968993) back to top