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anti-Human CCR5 antibody for Western Blotting

Recommended CCR5 Antibody (supplied by: Log in to see )

Antigen
Chemokine (C-C Motif) Receptor 5 (CCR5) Antibodies
  • AM4-7
  • CC-CKR-5
  • CCCKR5
  • CCR-5
  • CCR1-L
  • CCR5
  • CCR5-L
  • CD195
  • CKR-5
  • CKR5
  • Ckr5
  • CMKBR5
  • Cmkbr5
  • GPCR
  • IDDM22
Epitope
N-Term
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
Western Blotting (WB)
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Catalog No. ABIN306774
$ 269.50
Plus shipping costs $45.00

Top referenced anti-CCR5 antibody for Western Blotting

Similar anti-CCR5 Antibodies

Application / Reactivity Human
Western Blotting (WB) 1 Antibodies

General

Antigen Chemokine (C-C Motif) Receptor 5 (CCR5) Antibodies
Epitope N-Term
Reactivity Human
Host Rabbit
Clonality
Polyclonal
Application Western Blotting (WB)
Pubmed 7 references available
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Product Details anti-CCR5 Antibody

Target Details CCR5 Application Details Handling References for anti-CCR5 Antibody (ABIN306774) Images
Isotype IgG

Target Details CCR5

Product Details anti-CCR5 Antibody Application Details Handling References for anti-CCR5 Antibody (ABIN306774) Images back to top
Antigen
Alternative Name CCR5 (NT) (HIV and chemokine receptor) (CCR5 Antibody Abstract)
Background Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors1,2. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells3,4. CCR5 is required for the infection by HIV-1, HIV-2, and SIV1,2. The -chemokines RANTES, MIP-1 and MIP-1 are the ligands for CCR5 and prevent infection by M-tropic HIV-13-5. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells6,7. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites8. CCR5 messenger RNA is expressed in lymphoid organs and monocytes. Synonyms: Anti-CCR5 (N-terminal).
Pathways TCR Signaling

Application Details

Product Details anti-CCR5 Antibody Target Details CCR5 Handling References for anti-CCR5 Antibody (ABIN306774) Images back to top
Application Notes Detects CCR5 receptors by Western blot at 0.25 to 0.5 ug/ml. Detects an approximately 40 kDa band in THP-1 whole cell lysates. Positive Control: THP-1 whole cell lysates.
Restrictions For Research Use only

Handling

Product Details anti-CCR5 Antibody Target Details CCR5 Application Details References for anti-CCR5 Antibody (ABIN306774) Images back to top
Concentration 0.5 mg/ml
Storage -20 °C

References for anti-CCR5 Antibody (ABIN306774)

Product Details anti-CCR5 Antibody Target Details CCR5 Application Details Handling Images back to top
Background publications

Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998

Littman: "Chemokine receptors: keys to AIDS pathogenesis?" in: Cell, Vol. 93, Issue 5, pp. 677-80, 1998

Doranz, Lu, Rucker, Zhang, Sharron, Cen, Wang, Guo, Du, Accavitti, Doms, Peiper: "Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1." in: Journal of virology, Vol. 71, Issue 9, pp. 6305-14, 1997

Wu, Gerard, Wyatt, Choe, Parolin, Ruffing, Borsetti, Cardoso, Desjardin, Newman, Gerard, Sodroski: "CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 179-83, 1996

Trkola, Dragic, Arthos, Binley, Olson, Allaway, Cheng-Mayer, Robinson, Maddon, Moore: "CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 184-7, 1996

Deng, Liu, Ellmeier, Choe, Unutmaz, Burkhart, Di Marzio, Marmon, Sutton, Hill, Davis, Peiper, Schall, Littman, Landau: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996

Dragic, Litwin, Allaway, Martin, Huang, Nagashima, Cayanan, Maddon, Koup, Moore, Paxton: "HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5." in: Nature, Vol. 381, Issue 6584, pp. 667-73, 1996

Images

Product Details anti-CCR5 Antibody Target Details CCR5 Application Details Handling References for anti-CCR5 Antibody (ABIN306774) back to top
Supplier Images
Western Blotting (WB) image for anti-CCR5 antibody (Chemokine (C-C Motif) Receptor 5) (N-Term) (ABIN306774) Western blot analysis using anti- CCR5 (NT) antibody at 0.5 µg/ml on THP-1 whole cel...