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anti-Mouse (Murine) CD137 antibody for Functional Studies

Recommended CD137 Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) Antibodies
  • 4-1BB
  • A930040I11Rik
  • AA408498
  • AI325004
  • CD137
  • Cd137
  • CDw137
  • ILA
  • Ly63
  • TNFRSF9
  • zgc:136557
Reactivity
Mouse (Murine)
155
80
15
9
3
1
Host
Syrian Hamster
76
48
40
26
23
5
Clonality
Monoclonal
Conjugate
This CD137 antibody is un-conjugated
24
19
16
6
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS)
139
80
75
21
20
15
11
8
5
5
5
2
2
1
1
1
1
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Catalog No. ABIN282336
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008708442 ABIN1823224 Func FACS Hamster Log in to see ATM-2
0.0008708442 ABIN2478423 Func FACS Hamster IgG Log in to see 17B5 1
0.0008708442 ABIN1820001 Func FACS Hamster IgG Log in to see 17B5

Top referenced anti-CD137 antibody for Functional Studies

Similar anti-CD137 Antibodies

Application / Reactivity Mouse (Murine)
ELISA 4 Antibodies
Flow Cytometry (FACS) 65 Antibodies
Functional Studies (Func) 4 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 4 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Neutralization (Neut) 1 Antibodies
Western Blotting (WB) 19 Antibodies

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) Antibodies
Reactivity Mouse (Murine)
(155), (80), (15), (9), (3), (1)
Host Syrian Hamster
(76), (48), (40), (26), (23), (5)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD137 antibody is un-conjugated
(24), (19), (16), (6), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS)
(139), (80), (75), (21), (20), (15), (11), (8), (5), (5), (5), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-CD137 Antibody

Target Details CD137 Application Details Handling References for anti-CD137 Antibody (ABIN282336) Images
Specificity The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays.
Characteristics The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays.
Synonyms: Synonyms: Ly-63, TNFRSF9, ILA
Purification Affinity Purified
Endotoxin Level <0.001 ng endotoxin/μg
Grade Functional Grade
Clone 17B5
Isotype IgG

Target Details CD137

Product Details anti-CD137 Antibody Application Details Handling References for anti-CD137 Antibody (ABIN282336) Images back to top
Antigen
Alternative Name CD137 (TNFRSF9 Antibody Abstract)
Background CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Unpublished data suggest that 17B5 has strong agonistic effect in in vitro functional assays.
Research Area CD Antigens
Pathways TCR Signaling

Application Details

Product Details anti-CD137 Antibody Target Details CD137 Handling References for anti-CD137 Antibody (ABIN282336) Images back to top
Application Notes Applications reported: This 17B5 antibody has been reported for use in flow cytometric analysis and functional assays.

Applications tested: The 17B5 antibody has been tested by flow cytometric analysis of activated mouse splenocytes cultures. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Restrictions For Research Use only

Handling

Product Details anti-CD137 Antibody Target Details CD137 Application Details References for anti-CD137 Antibody (ABIN282336) Images back to top
Concentration 1 mg/mL
Buffer aqueous buffer, no sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Use in sterile environment.
Storage 4 °C

References for anti-CD137 Antibody (ABIN282336)

Product Details anti-CD137 Antibody Target Details CD137 Application Details Handling Images back to top
Background publications

Zheng, Wang, Chen: "The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 4, pp. 2428-34, 2004

Images

Product Details anti-CD137 Antibody Target Details CD137 Application Details Handling References for anti-CD137 Antibody (ABIN282336) back to top
Supplier Images
 image for anti-CD137 antibody (Tumor Necrosis Factor Receptor Superfamily, Member 9) (ABIN282336) Surface staining of ConA stimulated mouse splenocytes with anti-mouse CD137 (17B5) PE...