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|Application / Reactivity||Mouse (Murine)|
|Flow Cytometry (FACS)||65 Antibodies|
|Functional Studies (Func)||4 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||4 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||3 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Mass Cytometry (CyTOF)||1 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Western Blotting (WB)||19 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This CD137 antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
|6 references available|
|Supplier||Log in to see|
Product Details anti-CD137 AntibodyTarget Details CD137 Application Details Handling References for anti-CD137 Antibody (ABIN2663015) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details CD137Product Details anti-CD137 Antibody Application Details Handling References for anti-CD137 Antibody (ABIN2663015) Images back to top
|Alternative Name||CD137 (TNFRSF9 Antibody Abstract)|
|Background||CDw137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CDw137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CDw137 with its ligand, 4-1BBL (CDw137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation.|
|Research Area||Stem Cells, Hematopoietic Progenitors, Cytokines, Innate Immunity, CD Antigens, Apoptosis/Necrosis, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD137 Antibody Target Details CD137 Handling References for anti-CD137 Antibody (ABIN2663015) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD137 Antibody Target Details CD137 Application Details References for anti-CD137 Antibody (ABIN2663015) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-CD137 Antibody (ABIN2663015)Product Details anti-CD137 Antibody Target Details CD137 Application Details Handling Images back to top
Németh, Tóth, Hamari et al.: "Transcriptome profile of the murine macrophage cell response to Candida parapsilosis." in: Fungal genetics and biology : FG & B, Vol. 65, pp. 48-56, 2014 (PubMed).
del Rio, Cote-Sierra, Rodriguez-Barbosa: "Flt3L-mobilized dendritic cells bearing H2-Kbm1 apoptotic cells do not induce cross-tolerance to CD8+ T cells across a class I MHC mismatched barrier." in: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 24, Issue 5, pp. 501-13, 2011 (PubMed).
Nishimoto, Lee, Hong et al.: "Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor." in: Blood, Vol. 106, Issue 13, pp. 4241-8, 2005 (PubMed).
Lee, Vella, Kwon et al.: "Enhanced CD4 T cell responsiveness in the absence of 4-1BB." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 6803-8, 2005 (PubMed).
Schwarz, Blanco, von Kempis et al.: "ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival." in: Blood, Vol. 87, Issue 7, pp. 2839-45, 1996 (PubMed).
Alderson, Smith, Tough et al.: "Molecular and biological characterization of human 4-1BB and its ligand." in: European journal of immunology, Vol. 24, Issue 9, pp. 2219-27, 1994 (PubMed).
ImagesProduct Details anti-CD137 Antibody Target Details CD137 Application Details Handling References for anti-CD137 Antibody (ABIN2663015) back to top