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Browse our CD247 Proteins (CD247)

Full name:
CD247 Molecule Proteins (CD247)
On are 12 CD247 Molecule (CD247) Proteins from 6 different suppliers available. Additionally we are shipping CD247 Antibodies (203) and CD247 Kits (6) and many more products for this protein. A total of 232 CD247 products are currently listed.
4930549J05Rik, A430104F18Rik, AW552088, Cd3, Cd3-eta, CD3-ZETA, CD3H, CD3Q, Cd3z, Cd3zeta, CD247, im:7156386, LOC100136514, LOC100136549, LOC100305023, T3Z, Tcrk, TCRZ, TCRzeta
list all proteins Gene Name GeneID UniProt
CD247 12503 P29020,P24161
CD247 919 P20963
Rat CD247 CD247 25300  

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CD247 Proteins (CD247) by Origin

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Top referenced CD247 Proteins

  1. Human CD247 Protein expressed in Escherichia coli (E. coli) - ABIN1098500 : Rieux-Laucat, Hivroz, Lim, Mateo, Pellier, Selz, Fischer, Le Deist: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. in The New England journal of medicine 2006 (PubMed)
    Show all 2 references for ABIN1098500

More Proteins for CD247 Interaction Partners

Zebrafish CD247 Molecule (CD247) interaction partners

  1. The structure of the adaptor protein cd3zeta has been identified in the zebrafish genome.

Mouse (Murine) CD247 Molecule (CD247) interaction partners

  1. Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 (show CCR7 Proteins) and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice

  2. There is an early (within seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8 to MHC.

  3. The resting TCR localized in the disordered domain of giant plasma membrane (PM) vesicles (GPMVs) and PM spheres (PMSs) and single and nanoclustered TCRs are found in the high-density fractions in sucrose gradients.

  4. When Ly108 (show SLAMF6 Proteins) is engaged in trans during cell-cell interactions, Ly108 (show SLAMF6 Proteins)-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 (show SLAMF6 Proteins) TM domain, leading to more efficient CD3zeta dephosphorylation.

  5. Two transcription factor binding sites and a long non-coding RNA are identified within the Cd247 gene.

  6. Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK (show EPHB2 Proteins) and Egr (show EGR1 Proteins) activities leading to impaired positive selection.

  7. The results of this study supported the model that the procognitive function of CD3zeta may be mediated through its involvement in the NMDAR (show GRIN1 Proteins) downstream signaling pathway leading to CaMKII (show CAMK2G Proteins)-dependent LTP (show SCP2 Proteins) induction.

  8. T cell CD3zeta deficiency enables multiorgan tissue inflammation.

  9. Tyrosine phosphorylation of the TCR-zeta cytoplasmic domain regulates its association with the plasma membrane

  10. The data of this study suggested that CD3zeta mediates the ZAP-70 (show ZAP70 Proteins)/Syk (show SYK Proteins) kinase activation triggered by ephrinA-activated pathway to regulate early neuronal morphogenesis.

Human CD247 Molecule (CD247) interaction partners

  1. Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 (show CASP3 Proteins) activation in oral cancer.

  2. SRSF1 (show SRSF1 Proteins) regulates CD3zeta expression in human T cells and may contribute to the T cell defect in systemic lupus erythematosus.

  3. In localized colorectal cancer carriers, mRNA-based CD3Z/CD8 (show CD8A Proteins) profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 (show ESR1 Proteins) expression.

  4. Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

  5. we observed decreased CD3 (show CD3 Proteins) surface expression, reduced ZAP-70 (show ZAP70 Proteins) abundance and increased histone H3 (show HIST3H3 Proteins)-acetylation in activated T lymphocytes after 5 minutes of clinorotation and a transient downregulation of CD3 (show CD3 Proteins) and stable downregulation of IL-2R

  6. T cell receptor (TCR)-CD3 (show CD3 Proteins) complex and the Lck (show LCK Proteins) kinase were required for Ca(2 (show CA2 Proteins)+) mobilization but not for apoptosis induction in Jurkat cells.

  7. These findings confirm the role of PTPN22 (show PTPN22 Proteins) and CD28 (show CD28 Proteins) involved in the T cell activation pathway in the development of T1D in Tunisian families. Interestingly, ZAP70 (show ZAP70 Proteins) and TCRbeta/CD3z seem to contribute to the susceptibility to the disease in our population.

  8. a CD247 defect leads to the accumulation of naive, hyporesponsive gammadelta and alphabeta T cells in thymoma patient resulting in a novel type of acquired T cell immunodeficiency and immune dysregulation of clinical significance.

  9. CD247 downregulation was associated with disease severity, complications, and the occurrence of future cardiovascular events, suggesting its potential use not only as a diagnostic but also as a prognostic biomarker.

  10. Data indicate that the decreasing trend in the expression level of TCRzeta chain, ZAP-70 (show ZAP70 Proteins) kinase and epsilon Fc Receptors FcvarepsilonRIgamma was significantly associated with disease progression.

Pig (Porcine) CD247 Molecule (CD247) interaction partners

CD247 Protein Profile

Protein Summary

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with CD247

  • CD247 antigen like (cd247l)
  • CD3zeta-2 (LOC100136514)
  • CD3zeta-1 (LOC100136549)
  • CD3 zeta (LOC100305023)
  • CD247 molecule (CD247)
  • CD247 antigen (cd247)
  • CD247 antigen (Cd247)
  • Cd247 molecule (Cd247)
  • 4930549J05Rik protein
  • A430104F18Rik protein
  • AW552088 protein
  • Cd3 protein
  • Cd3-eta protein
  • CD3-ZETA protein
  • CD3H protein
  • CD3Q protein
  • Cd3z protein
  • Cd3zeta protein
  • CD247 protein
  • im:7156386 protein
  • LOC100136514 protein
  • LOC100136549 protein
  • LOC100305023 protein
  • T3Z protein
  • Tcrk protein
  • TCRZ protein
  • TCRzeta protein

Protein level used designations for CD247 Molecule Proteins (CD247)

CD247 antigen like , cd3zetal , CD3zeta-like , CD247 antigen-like , CD3zeta-2 , T-cell surface glycoprotein CD3 zeta chain , CD3zeta-1 , CD3 zeta , CD247 molecule , cd3zeta , CD3 antigen, zeta polypeptide , CD3-zeta/eta , T-cell receptor T3 eta chain , CD247 antigen, zeta subunit , CD3Z antigen, zeta polypeptide (TiT3 complex) , CD3zeta chain , T-cell antigen receptor complex, zeta subunit of CD3 , T-cell receptor T3 zeta chain , TCR zeta chain , CD247 antigen , T-cell receptor CD3 subunit zeta , T-cell receptor CD3, subunit zeta , CD3 zeta chain , CD3 Zeta chain

100101465 Danio rerio
100136514 Salmo salar
100136549 Salmo salar
100305023 Ictalurus punctatus
748272 Pan troglodytes
100101654 Danio rerio
12503 Mus musculus
919 Homo sapiens
25300 Rattus norvegicus
397302 Sus scrofa
100008617 Oryctolagus cuniculus
443436 Ovis aries
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