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Position 35 of CD3epsilon was important and substitution of amino acid A for V at this position greatly reduced T-cell reactivity to FN18 monoclonal antibody.
Data show that anti-CD3 (show CD3 Proteins) monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 (show CD3 Proteins) MAb isotype and is not governed by Siglec expression.
The data show that CD3epsilon chain couples to Cbl via simultaneous binding of both proteins to Numb, thus mediating TCR degradation
IL-17 (show IL17A Proteins)-producing CD3(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation.
these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.
these results indicate that membrane association of the CD3epsilon signaling domain is required for optimal thymocyte development and peripheral T cell function.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT (show LAT Proteins) and PLCgamma1 (show PLCG1 Proteins) in Dow2-induced anergic T cells. The novel CD3-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
that Nck (show NCK1 Proteins) recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck (show NCK1 Proteins)-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response.
Structure of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled structural comparisons of antibody-liganded and unliganded forms of CD3epsilon revealing that antibody binding does not induce any substantial rearrangements within CD3epsilon.
CFTR (show CFTR Proteins) dysfunction in T cells can lead directly to aberrant immune responses in CD3+ lymphocytes
analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
Polymorphisms of the CD3varepsilon ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 antibody binding.
expressed and refolded porcine CD3 (show CD3 Proteins) ectodomain molecules include CD3epsilon, CD3gamma, CD3delta (show CD3D Proteins), CD3epsilongamma heterodimer, CD3epsilondelta heterodimer, CD3epsilongamma single-chain fusion protein and CD3epsilondelta single-chain fusion protein
the stalk domains of NKp30 (show NCR3 Proteins) and NKp46 (show NCR1 Proteins), another NCR employing CD3zeta (show CD247 Proteins) for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling.
The inducible recruitment of WASp to the TCR-CD3 (show CD3 Proteins) complex is partially dependent of tyrosine phosphorylation of Cd3e.
increase. Our results indicate that the change in CD3zeta-chain (show CD247 Proteins) expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma.
Data suggest that HIV-1 gp41 transmembrane domain (TMD (show TTN Proteins)) directly interacts with TMDs of the T-cell receptor and it's CD3 (show CD3 Proteins)-antigen co-receptors (delta, gamma, and epsilon); these interactions appear to be involved in immune evasion mechanism of HIV-1.
The docking site for CD3 (show CD3 Proteins) subunits on the T Cell receptor beta chain has been identified by solution NMR.
analysis of the molecular organization of the TCR-CD3 (show CD3 Proteins) complex
ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients.
Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation.
Altered expression of the TCR signaling related genes CD3 (show CD3 Proteins) and FcepsilonRIgamma in patients with aplastic anemia.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
, CD3e molecule, epsilon (CD3-TCR complex)
, CD3E antigen, epsilon polypeptide (TiT3 complex)
, T-cell surface antigen T3/Leu-4 epsilon chain
, T-cell surface glycoprotein CD3 epsilon chain
, CD3 antigen, epsilon polypeptide
, CD3 molecule, epsilon polypeptide
, CD3 epsilon subunit
, CD3e antigen, epsilon polypeptide (TiT3 complex)
, T-cell antigen receptor complex, epsilon subunit of T3
, antigen CD3E, epsilon polypeptide (TiT3 complex)
, CD3 antigen epsilon
, CD3E antigen, epsilon polypeptide
, TiT3 complex
, CD3 Epsilon chain